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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
285 Results for "
purify
" in MedChemExpress (MCE) Product Catalog:
Products (285)
285 Results for "purify" in MCE Product Catalog:
238
238 Publications Verification
Synonyms: CBIC2
113
113 Cited Publications
Art. -Nr.: HY-18723
CAS. Nr.: 448947-81-7
Target:
Forschungsgebiete:
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation .
95
Target:
Forschungsgebiete:
Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .
95
95 Cited Publications
Art. -Nr.: HY-50898A
CAS. Nr.: 388082-77-7
Synonyms: GW572016 ditosylate; GW2016 ditosylate
Target:
Forschungsgebiete:
Lapatinib ditosylate (GW572016 ditosylate) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .
95
95 Cited Publications
Art. -Nr.: HY-50898B
CAS. Nr.: 388082-78-8
Synonyms: GW572016 ditosylate monohydrate; GW2016 ditosylate monohydrate
Target:
Forschungsgebiete:
Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .
66
66 Cited Publications
Synonyms: Tripterine; Tripterin
47
47 Cited Publications
Art. -Nr.: HY-50662
CAS. Nr.: 844499-71-4
Target:
Forschungsgebiete:
A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .
40
40 Cited Publications
Art. -Nr.: HY-108882B
CAS. Nr.: 9003-98-9
Target:
Forschungsgebiete:
DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune responses. Decreased DNase I activity may be associated with the onset and progression of systemic lupus erythematosus (SLE). DNase I (RNase & Protease free) is a molecular biology-grade DNase I purified by chromatography to remove RNase and protease .
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31
31 Cited Publications
Forschungsgebiete:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC50 of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD. SB 239063 can penetrate the blood brain barrier (BBB) .
23
23 Cited Publications
Synonyms: Mallotoxin; NSC 56346; NSC 94525
17
17 Cited Publications
Synonyms: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate
17
17 Cited Publications
Synonyms: TXA127; Angiotensin (1-7); Ang-(1-7)
16
16 Cited Publications
Art. -Nr.: HY-P0239
CAS. Nr.: 92000-76-5
Target:
16
16 Cited Publications
Art. -Nr.: HY-P0239A
Target:
11
7
7 Cited Publications
7
7 Cited Publications
Target:
Forschungsgebiete:
KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays . KH7 is also a cAMP inhibitor .
6
5
5 Cited Publications
Forschungsgebiete:
Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
