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JC-1

(Synonyms: CBIC2)
217 Cited Publications
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Based on 217 publication(s) in Google Scholar

JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm).

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  • Reinheit: 98.05%
  • CAS. Nr.: 3520-43-2
  • Formel: C25H27Cl4IN4
  • Molecular Weight:652.23
  • Speicherung:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • JC-1 Chemical Structure
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • JC-1 Chemical Structure
    JC-1 Chemical Structure
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
  • Experimental Validation Results for JC-1
CAS. Nr.: 3520-43-2
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  • JC-1 Chemical Structure
    JC-1 Chemical Structure
    1/16
  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2022 Apr 26;16(4):6064-6079. [Abstract]

    Customer Validation
     To investigate the mitochondrial membrane potential, ACCO is stained with JC-1 for 30 min, washed with PBS, and analyzed by flow cytometry using 488 nm excitation with 530/30 and 585/42 nm band-pass filters.

  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2022 May;179:106123. [Abstract]

    Customer Validation
     Mitochondrial membrane potential (Δψm) is measured with fluorochrome dye JC-1 (15 μM; 37 °C for 30 min in darkness). Flow cytometry was used to measure red (aggregation of JC-1) and green (monomeric JC-1) fluorescence intensity in HUVECs.

  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: Small. 2021 Aug;17(32):e2101368. [Abstract]

    Customer Validation
     Laser scanning confocal fluorescence microscopy images of HT-1080 cells treated with different nanodrugs for the detection of intracellular lipid peroxidation and total ROS using C11-BODIPY and DCFH-DA as the corresponding fluorescence probes. Scale bar: 100 µm.

  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: Small. 2021 Feb;17(7):e2005865. [Abstract]

    Customer Validation
     In 4T1 cells, A549 cells, and HeLa cells, cells are treated with JC-1 (5 µg/mL) for 20 min in the darkness, the fluorescence is observed by flow cytometry and the fluorescent color of the cells was observed with a fluorescence microscope, respectively

  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: Small. 2021 Feb;17(7):e2005865. [Abstract]

    Customer Validation
     In 4T1 cells, A549 cells, and HeLa cells, cells are treated with JC-1 (5 µg/mL) for 20 min in the darkness, the fluorescence is observed by flow cytometry and the fluorescent color of the cells was observed with a fluorescence microscope, respectively

  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2019 Apr 10;18(1):85. [Abstract]

    Customer Validation
     KRA-533 induces caspase 3 activation and reduces mitochondrial membrane potential in NSCLC cells. The measurement of mitochondrial membrane potential by JC-1 staining.

  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: Small. 2019 Sep;15(36):e1902642. [Abstract]

    Customer Validation
     H9C2 cells are rinsed with pre-cooled PBS for 3 times and collected in PBS buffer containing 10 µg/mL JC-1 probe. After incubation for 20 min in dark place, cells are rinsed with PBS twice by centrifugation to remove the supernatant. Finally, H9C2 cell pellets suspended in PBS are analyzed by a flow cytometric analyzer.

  • 1/16

    JC-1 purchased from MedChemExpress. Usage Cited in: New J Chem. 2017 41(23).

    Customer Validation
     Measurement of mitochondria membrane potential by JC-1 staining. HeLa cells are incubated with or without WOs for 24 h, followed by NIR irradiation for NIR and WOs + NIR groups.

  • JC-1