Art. -Nr.: HY-50662

A-769662

47 Cited Publications

Kundenbewertung

Based on 47 publication(s) in Google Scholar

A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC₅₀ = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC₅₀ = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.33%
CAS. Nr.: 844499-71-4
Formel: C₂₀H₁₂N₂O₃S
Molecular Weight:360.39

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

A-769662 Chemical Structure

CAS. Nr.: 844499-71-4

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (47)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

AMPK

0.8 μM (EC₅₀)

Alle AMPK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Hepatocyte	IC₅₀	3.2 μM Compound: 2, A-769662	Activation of AMPK in rat primary hepatocytes assessed as inhibition of fatty acid biosynthesis by 14C-acetate incorporation assay Activation of AMPK in rat primary hepatocytes assessed as inhibition of fatty acid biosynthesis by 14C-acetate incorporation assay	[PMID: 24900695]

In Vitro

A-769662 (0.1-100 μM) increases AMPK activity in the presence of a saturating concentration of AMP (300 μM)^[1].
A-769662 (1 nM-1 mM, 4h) increases acetyl-CoA carboxylase (ACC) phosphorylation dose-dependently in primary rat hepatocytes^[1].
A-769662 (50-300 μM, 1 h) increases the GFP-dependent fluorescence dose-dependently in HEK-GFPu-1 cells^[3].
A-769662 (0-50 μM, 1 h) is able to reduce the activity of pre-existing proteasomal activity in MEF cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Primary rat hepatocytes
Concentration:

Primary rat hepatocytes
Incubation Time:

4 h
Result:

Increased ACC phosphorylation dose-dependently.
Showed that increased ACC phosphorylation correlated with inhibition of fatty acid synthesis as measured by incorporation of ¹⁴C-acetate into fatty acids with IC₅₀ of 3.2 μM.

In Vivo

A-769662 (30 mg/kg, i.p., single dose) significantly reduces the respiratory exchange ratio relative to vehicle, indicating increased fatty acid utilization despite the availability of carbohydrates in Sprague Dawley rats^[1].
A-769662 (3-30 mg/kg, i.p., b.i.d., for 5 d) reduces plasma glucose levels, lipids, and ACC activity in ob/ob and lean littermate mice^[1].
A-769662 (3-30 mg/kg, i.p., b.i.d., for 14 d) reduces plasma glucose in ob/ob and lean littermate mice^[1].
A-769662 (10-300 μM, 1 h) inhibits the proteasomal function in mouse embryonic fibroblast (MEF) cells with an IC₅₀ of 62 μM in wild-type and double α1 -/- α1 -/- KO mice ^[3].
A-769662 (300 μM) has toxic effects on MEF cells in wild-type and double α1 -/- α1 -/- KO mice^[3].
A-769662 (15-30 mg/kg, i.p., 2 w) induces AMPK activation that normalizes the nerve functional changes and reduces pain associated with diabetic neuropathy (DN) in diabetic mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley rats fed ad libitum prior were first acclimated by placing them in a gas exchange indirect calorimeter without food for 2 h then gavaged with a mixed meal plus A-769662^[1]
Dosage:

30 mg/kg
Administration:

Intraperitoneal injection (i.p.), single dose
Result:

Resulted in 33% reduction of malonyl CoA levels in livers of treated animals in relative to the vehicle.
Had a statistically nonsignificant decrease in malonyl CoA levels in skeletal muscle of rats treated with A-769662.

Animal Model:

6- to 7-weeks-old ob/ob and lean littermate mice^[3]
Dosage:

3 or 30 mg/kg b.i.d. for 5 days; 3, 10, or 30 mg/kg b.i.d. for 14 days
Administration:

Intraperitoneal injection (i.p.)
Result:

Significantly decreases fed plasma glucose (30-40% reduction) at 30 mg/kg in both 5 d and 14 d studies.
Reduced 42% of the fed glucose levels (16 h postdose) in the 5 day study.
Resulted in a modest reduction in body weight gain in ob/ob mice treated with 30 mg/kg dose for 5 days.
Resulted in a transient reduction in food intake in the 14 d study.
Increased the compound concentrations in liver 1 h after 30 or 3 mg/kg of A-769662 approximately 30-fold or 2.5-fold above the cellular IC₅₀ for fatty acid synthesis.

Animal Model:

Healthy male Sprague-Dawley rats (250-270 g) fed on standard diet and water ad libitum then induced diabetes with Streptozotocin (HY-13753) (55 mg/kg, i.p.)^[4]
Dosage:

15 or 30 mg/kg for 14 days
Administration:

Intraperitoneal injection (i.p.)
Result:

Attenuated the pain hypersensitivity and resulted in improved tail flick latencies and paw withdrawal threshold.
Resulted in marked reduction in motor/sensory nerve conduction velocities (MNCV and SNCV) as well as restoring impaired nerve blood flow (NBF).
Significantly reduced TUNEL-positive cells, inhibited the lipid peroxidation and improved the antioxidant defence by improving glutathione levels in the sciatic nerves of treated diabetes rats.
Significantly reduces the expression of IL-6 and TNF-α and reduced the expression of NF-κB and COX-2 compared to diabetic rats.
Reversed AMPK inactivation and associated mitochondrial biogenesis and autophagy deficits in diabetic rats.
Significantly elevated mitochondrial ATP production in treated rats.

Chemical Information

CAS. Nr. 844499-71-4
Appearance Solid
Molecular Weight 360.39
Formel C₂₀H₁₂N₂O₃S
Color Off-white to yellow
SMILES

N#CC1C(C2=C(NC1=O)SC=C2C3=CC=C(C4=CC=CC=C4O)C=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (47)

All RT-PCRWBFlow Cytometry

Sort by:

Journal Impact Factor

Nat Nanotechnol

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. [Abstract]

2021 Jul;16(7):830-839. PMID: 33958764
Cell Metab

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress. [Abstract]

2019 Jul 2;30(1):157-173.e7 PMID: 31155494
Immunity

Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance. [Abstract]

2024 Jun 11;57(6):1289-1305.e9. PMID: 38772366

A-769662 purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Jun 11;57(6):1289-1305.e9. [Abstract]

Immunoblots of P-AMPK and total AMPK in VAT ILC2s.VAT ILC2s sorted fromId2 cre-ERT2 andId2 cre-ERT2Stk11f/f mice 5 days post tamoxifen administration were treated with A-769662 (2μM) in vitro for 5 days.

A-769662 purchased from MedChemExpress. Usage Cited in: Immunity. 2024 Jun 11;57(6):1289-1305.e9. [Abstract]

Frequency of IL-5⁺ ILC2s (left), IL-13⁺ILC2s (right).VAT ILC2s sorted fromId2 cre-ERT2 andId2 cre-ERT2Stk11 f/f mice 5 days post tamoxifen administration were treated with A-769662 (2μM) in vitro for 5 days.
Cancer Commun (Lond)

Orchestrated desaturation reprogramming from stearoyl-CoA desaturase to fatty acid desaturase 2 in cancer epithelial-mesenchymal transition and metastasis. [Abstract]

2025 Mar;45(3):245-280. PMID: 39722173

A-769662 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Mar;45(3):245-280. [Abstract]

Western blotting of CDH2, phosphorylated AMPKαThr172, and phosphorylated S6Ser235/236 in SW780 and MCF7 treated 48 h with A939572 (10 µmol/L), A-769662 (A769662;100 µmol/L), and Rapamycin (20 µmol/L).

A-769662 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Mar;45(3):245-280. [Abstract]

RT-qPCR measurement of CDH2, CDH1, SNAI2, and FABP4 in SW780 and MCF7 after A-769662（A769662） treatment (100 µmol/L； 48 h).
Nat Cell Biol

Stress granules restrain ferroptosis by sequestering ferritin. [Abstract]

2026 Jun;28(6):1204-1218. PMID: 42174134
Mol Cell

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation. [Abstract]

2017 Oct 19;68(2):336-349.e6. PMID: 29053957

A-769662 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2017 Oct 19;68(2):336-349.e6. [Abstract]

AMPK DKO SV40-immortalized MEFs are electroporated with plasmids encoding Myc-tagged AMPK α1, Myc-tagged AMPK α2 and Myc-tagged AMPK α2 S > A. 48 hr later, MEFs are starved for 3 hr and treated for 2 hr with DMSO or 50 mM A769662 before protein extraction. Western blot analysis shows the A769662-induced ACC phosphorylation in transfected cells.
Nat Commun

A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma. [Abstract]

2025 Feb 18;16(1):1736. PMID: 39966385
Nat Commun

The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling. [Abstract]

2025 Feb 4;16(1):1343. PMID: 39905041
Nat Commun

Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation. [Abstract]

2023 Dec 14;14(1):8316. PMID: 38097578
Nat Commun

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. [Abstract]

2019 Feb 6;10(1):620. PMID: 30728358
J Nanobiotechnology

Precision mitochondrial delivery for tissue repair in intervertebral disc degeneration. [Abstract]

2026 Jun 14. PMID: 42289699
J Biomed Sci

Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA. [Abstract]

2023 Nov 7;30(1):91. PMID: 37936170
Metabolism

KCMF1 promotes MASLD progression via K48-linked ubiquitination and degradation of AMPKα. [Abstract]

2026 May 20:182:156651. PMID: 42162901
J Neuroinflammation

Microglia-derived TNF-α contributes to RVLM neuronal mitochondrial dysfunction via blocking the AMPK-Sirt3 pathway in stress-induced hypertension. [Abstract]

2023 Jun 1;20(1):137. PMID: 37264405
Cell Commun Signal

Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy. [Abstract]

2023 May 4;21(1):99. PMID: 37143083
Cell Commun Signal

Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth. [Abstract]

2022 Jul 16;20(1):105. PMID: 35842652
Int J Biol Macromol

CD36 molecule and AMP-activated protein kinase signaling drive docosahexaenoic acid-induced lipid remodeling in goat mammary epithelial cells. [Abstract]

2025 May 8;311(Pt 4):144076. PMID: 40348225
Acta Pharmacol Sin

Hepatocyte cellular repressor of E1A-stimulated genes 1 protects against acetaminophen-induced liver injury by promoting autophagy. [Abstract]

2025 Mar 25. PMID: 40133627
Phytomedicine

Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy. [Abstract]

2025 Dec 9:150:157688. PMID: 41453294
Phytomedicine

Keluoxin reduces renal lipid deposition in diabetic nephropathy via AMPK/NF-κB-mediated mtabolic regulation. [Abstract]

2025 May 19:145:156776. PMID: 40578033
EMBO J

Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes. [Abstract]

2024 Dec;43(24):6383-6409. PMID: 39496977
EMBO Mol Med

Metabolic switch from fatty acid oxidation to glycolysis in knock-in mouse model of Barth syndrome. [Abstract]

2023 Sep 11;15(9):e17399. PMID: 37533404
Cell Chem Biol

The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK. [Abstract]

2026 Jun 18;33(6):767-784.e7. PMID: 42061410
Cell Rep

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]

2025 Jun 13;44(6):115851. PMID: 40516055
Cell Rep

circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. [Abstract]

2022 Nov 22;41(8):111707. PMID: 36417875
Food Biosci

2026 Jun 8;81:109140.
Front Immunol

Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis. [Abstract]

2018 Dec 18:9:3026. PMID: 30619366
Int Immunopharmacol

OTUD1 inhibits macrophage ferroptosis via regulation of AMPK and GSK3β/β-catenin signaling pathways exerting protective effects in sepsis-induced acute lung injury. [Abstract]

2025 Jun 2:160:114985. PMID: 40460602
Int Immunopharmacol

Sialic acids promote macrophage M1 polarization and atherosclerosis by upregulating ROS and autophagy blockage. [Abstract]

2023 Jul:120:110410. PMID: 37270929
Mol Neurobiol

Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation. [Abstract]

2017 Apr;54(3):2301-2312. PMID: 26957299

A-769662 purchased from MedChemExpress. Usage Cited in: Mol Neurobiol. 2017 Apr;54(3):2301-2312. [Abstract]

Effect of A769662 on high glucose-induced inflammatory changes in N2A cells and inflammatory marker expression in sciatic nerves of STZ induced rats. Representative immunoblot images of iNOS, COX-2, NF-κB, β-actin and corresponding graphical representations of densitometric analysis.
Biochim Biophys Acta Mol Basis Dis

Pharmacological targeting of AMPK to restore glucose and fatty acid metabolism homeostasis attenuates transplanted kidney fibrosis. [Abstract]

2024 Sep 13:167510. PMID: 39278511
J Cell Mol Med

Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats. [Abstract]

2021 Aug;25(16):7642-7659. PMID: 34169635
Sci Rep

AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections. [Abstract]

2021 Jun 11;11(1):12387. PMID: 34117280
J Diabetes

Duodenal-jejunal bypass surgery activates eNOS and enhances antioxidant system by activating AMPK pathway to improve heart oxidative stress in diabetic cardiomyopathy rats. [Abstract]

2024 Jul;16(7):e13516. PMID: 38087869
Mol Cell Endocrinol

Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions. [Abstract]

2022 May 1:547:111598. PMID: 35157929
Viruses

Fatty Acids Regulate Porcine Reproductive and Respiratory Syndrome Virus Infection via the AMPK-ACC1 Signaling Pathway. [Abstract]

2019 Dec 10;11(12):1145. PMID: 31835577
Andrology

In vitro exposure to metformin activates human spermatozoa at therapeutically relevant concentrations. [Abstract]

2020 May;8(3):663-670. PMID: 31944615
Immunol Res

Metformin suppresses gammadelta T17 cell differentiation alleviating DSS-induced colitis. [Abstract]

2025 Feb 11;73(1):49. PMID: 39934569
Mol Immunol

Autotaxin promotes the degradation of the mucus layer by inhibiting autophagy in mouse colitis. [Abstract]

2023 Aug:160:44-54. PMID: 37356325
J Appl Toxicol

Capacitation-Induced Changes in Sperm Motility, AMPK Phosphorylation, and Tyrosine Phosphorylation Are Diminished by Therapeutically Relevant Concentrations of Metformin. [Abstract]

2026 Feb 2. PMID: 41628886
PLoS One

Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway. [Abstract]

2024 Mar 7;19(3):e0296792. PMID: 38452099
Reprod Sci

Modulation of Autophagy Through Regulation of 5'-AMP-Activated Protein Kinase Affects Mitophagy and Mitochondrial Function in Primary Human Trophoblasts. [Abstract]

2021 Aug;28(8):2314-2322. PMID: 33619701
Biochem Biophys Res Commun

CD39 is induced by nutrient deprivation in colorectal cancer cells and contributes to the tolerance to hypoxia. [Abstract]

2024 Oct 20:730:150367. PMID: 38991255
Virus Genes

AMP-activated kinase regulates porcine reproductive and respiratory syndrome virus infection in vitro. [Abstract]

2022 Apr;58(2):133-142. PMID: 35254586
bioRxiv

Adiponectin Signaling Regulates Urinary Bladder Function by Blunting Smooth Muscle Purinergic Contractility. [Abstract]

2024 Oct 29:2024.10.25.620328. PMID: 39554160
Research Square Preprint

2021 Dec.
Patent

US20180263995A1.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (138.74 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7748 mL

13.8739 mL

27.7477 mL

5 mM

0.5550 mL

2.7748 mL

5.5495 mL

10 mM

0.2775 mL

1.3874 mL

2.7748 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (290 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cool B, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab, 2006, 3(6), 403-416. [Content Brief]

[2]. Sanders MJ, et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem, 2007, 282(45), 32539-32548. [Content Brief]

[3]. Moreno D, et al, A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism. FEBS Lett, 2008, 583(17), 2650-2654. [Content Brief]

[4]. Yerra VG, et al. Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation. Mol Neurobiol. 2017 Apr;54(3):2301-2312. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7748 mL	13.8739 mL	27.7477 mL	69.3693 mL
	5 mM	0.5550 mL	2.7748 mL	5.5495 mL	13.8739 mL
	10 mM	0.2775 mL	1.3874 mL	2.7748 mL	6.9369 mL
	15 mM	0.1850 mL	0.9249 mL	1.8498 mL	4.6246 mL
	20 mM	0.1387 mL	0.6937 mL	1.3874 mL	3.4685 mL
	25 mM	0.1110 mL	0.5550 mL	1.1099 mL	2.7748 mL
	30 mM	0.0925 mL	0.4625 mL	0.9249 mL	2.3123 mL
	40 mM	0.0694 mL	0.3468 mL	0.6937 mL	1.7342 mL
	50 mM	0.0555 mL	0.2775 mL	0.5550 mL	1.3874 mL
	60 mM	0.0462 mL	0.2312 mL	0.4625 mL	1.1562 mL
	80 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8671 mL
	100 mM	0.0277 mL	0.1387 mL	0.2775 mL	0.6937 mL

Keywords

A-769662

47 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

A-769662

Epigenetics Compound Library

PI3K/Akt/mTOR Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Anti-diabetic Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Lipid Metabolism Compound Library

Glucose Metabolism Compound Library

Pain-Related Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) A-769662

Alle AMPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (47)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

A-769662

Epigenetics Compound Library

PI3K/Akt/mTOR Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Anti-diabetic Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Lipid Metabolism Compound Library

Glucose Metabolism Compound Library

Pain-Related Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) A-769662

Alle AMPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (47)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

A-769662 Related Classifications

HY-50662 Related Classifications