YB-3–17
YB-3-17 is a bifunctional molecule, that inhibits mTOR (IC50=0.22 nM) or degrades G1 to S phase transition 1 gene (GSPT1, DC50=5 nM) in a PROTAC mechanism. YB-3-17 exhibits antiproliferative activity in multi glioblastoma cell lines with IC50 of nanomolare levels. YB-3-17 exhibits antitumor efficacy in mouse models.
(Pink: GSPT1 Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker (HY-A0102)).
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- CAS. Nr.: 2940242-88-4
- Formel: C38H39N11O6
- Molecular Weight:745.79
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
IC50: 0.22 nM (mTOR)
DC50: 5 nM (GSPT1)
Chemical Information
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CAS. Nr. 2940242-88-4
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Molecular Weight 745.79
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Formel C38H39N11O6
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SMILES
NC(O1)=NC2=C1C=CC(C3=NN(C4CCN(C(C5CCC(CNC6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)CC4)C9=NC=NC(N)=C93)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
YB-3–17 Related Classifications
HY-170405 Related Classifications
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