Irs1 - insulin receptor substrate 1 Gene

Also Known as G972R; IRS-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16367

Summary

Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in cellular response to fatty acid. Acts upstream of or within several processes, including cellular response to Insulin stimulus; positive regulation of phosphatidylinositol 3-kinase activity; and protein kinase B signaling. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (Insulin Receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Irs1 Products (1)

mRNA Protein Name
NM_010570.4 NP_034700.2 insulin receptor substrate 1
Protein Preferred Names Protein Names

insulin receptor substrate 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-153479 Aganirsen Inhibitor / Phase 3
HY-153479A Aganirsen sodium Inhibitor / Phase 3
HY-145935 NT219 Inhibitor 98.57% Phase 2
HY-115461 MID-1 Inhibitor 99.67% Phase 2
HY-113402B Gamma-glutamylcysteine ammonium / Phase 1

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113402 Gamma-glutamylcysteine 98.53% Unkown
HY-100037 NT157 Inhibitor 99.38% Unkown
HY-12557 γ-Glutamylvaline 99.94% Unkown
HY-113402A Gamma-glutamylcysteine TFA 96.68% Unkown
HY-145733 DI-1859 99.62% Unkown
HY-B1885 Fenitrothion 99.43% Unkown
HY-N0479 Licarin B Activator 99.93% Unkown
HY-165035 Glucosylceramide (gaucher's spleen) 98.0% Unkown
HY-161321 PTP1B-IN-24 98.46% Unkown
HY-113402R Gamma-glutamylcysteine (Standard) 98.14% Unkown
HY-N2421 Sequoyitol 98.0% Unkown
HY-15113A Y-29794 tosylate Inhibitor 99.86% Unkown
HY-N3542 Carpachromene Inhibitor 98.84% Unkown
HY-N3628 Coronarin A Inhibitor ≥98.0% Unkown
HY-113402AR Gamma-glutamylcysteine TFA (Standard) 95.17% Unkown
HY-15113 Y-29794 Inhibitor / Unkown
HY-162499 MY17 Inhibitor / Unkown
HY-182558 Nandinine / Unkown
HY-184703 Antidiabetic agent 9 Activator / Unkown
HY-B1885S Fenitrothion-d6 / Unkown
HY-N0479S Licarin B-d4 / Unkown
HY-N20708 Chiisanogenin / Unkown
HY-P11902 IRS1 / Unkown
HY-P5433F IRS-1 Peptide, FAM labeled Substrate / Unkown
HY-RS06917 IRS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107758 Y-29794 oxalate Inhibitor / Unkown
HY-N10035 Cyclocarioside H / Unkown
HY-N3055 Pinusolide 99.93% Unkown
HY-RS16895 Irs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23337 Irs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irs1 NCBI NCBI:3667