Cyclocarioside H
Cyclocarioside H is an AMPK agonist. Cyclocarioside H suppresses inflammatory insult-induced IKKβ phosphorylation, alleviates IRS-1 serine hyperphosphorylation and restores insulin-triggered Akt activation in differentiated 3T3-L1 adipocytes. Cyclocarioside H enhances insulin-independent and insulin-mediated 2-NBDG glucose uptake to improve adipocyte insulin resistance under inflammatory stress. Cyclocarioside H can be used for research on inflammation-associated type 2 diabetes and insulin resistance.
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- CAS No.: 1403937-87-0
- Formule: C43H72O13
- Masse moléculaire:797.04
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Cyclocarioside H (2-20 µM; 4 h) increases glucose consumption in a dose-dependent manner in 3T3-L1 cells[1].
Cyclocarioside H (10 µM; 30 min) reduces inflammatory insult-triggered Ikkβ phosphorylation and positively regulates AMPK activation in adipocytes[1].
Cyclocarioside H (10 µM; 30 min) abolishes the reduction in glucose uptake induced by Mac-CM in adipocytes[1].
Cyclocarioside H (10 µM; 30 min) estores insulin-mediated phosphorylation levels of IRS-1 tyrosine residues and Akt in adipocytes[1].
Cyclocarioside H (10 µM; 30 min) increases insulin-mediated glucose uptake in adipocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Adipocytes
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Concentration:10 µM
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Incubation Time:30 min
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Result:Increased p-AMPK protein levels.
Decreased Ikkβ phosphorylation induced by the inflammatory insult.
Reduced the phosphorylation level of IRS-1 (S307) enhanced by Mac-CM treatment.
Chemical Information
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CAS No. 1403937-87-0
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Masse moléculaire 797.04
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Formule C43H72O13
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SMILES
C[C@]12[C@@]([C@](CC1)([C@@]3(C)O[C@@H]([C@](C)(C)O)CC3)[H])([C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](C)O4)C[C@]5([C@@]2(C)CC[C@@]6([C@]5(C)CC[C@@H](O[C@@H]7O[C@@H](COC(C)=O)[C@H](O)[C@H]7O)C6(C)C)[H])[H])[H]
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclocarioside H Related Classifications
HY-N10035 Related Classifications
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