1403937-87-0
Chemical Structure
Cyclocarioside H
- CAS No.: 1403937-87-0
- Formula:C43H72O13
- Molecular Weight:797.04
IUPAC Name: ((2S,3R,4R,5R)-3,4-dihydroxy-5-(((3R,5R,8R,9R,10R,12R,13R,14R,17S)-17-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-4,4,8,10,14-pentamethyl-12-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)tetrahydrofuran-2-yl)methyl acetate
InChIKey: DTIMJEQQKUQIDR-XLXWZXARSA-N
SMILES: C[C@]12[C@@]([C@](CC1)([C@@]3(C)O[C@@H]([C@](C)(C)O)CC3)[H])([C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](C)O4)C[C@]5([C@@]2(C)CC[C@@]6([C@]5(C)CC[C@@H](O[C@@H]7O[C@@H](COC(C)=O)[C@H](O)[C@H]7O)C6(C)C)[H])[H])[H]
Biological Activity: Cyclocarioside H is an AMPK agonist. Cyclocarioside H suppresses inflammatory insult-induced IKKβ phosphorylation, alleviates IRS-1 serine hyperphosphorylation and restores insulin-triggered Akt activation in differentiated 3T3-L1 adipocytes. Cyclocarioside H enhances insulin-independent and insulin-mediated 2-NBDG glucose uptake to improve adipocyte insulin resistance under inflammatory stress. Cyclocarioside H can be used for research on inflammation-associated type 2 diabetes and insulin resistance[1].
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Cyclocarioside H | Cyclocarioside H is an AMPK agonist. Cyclocarioside H suppresses inflammatory insult-induced IKKβ phosphorylation, alleviates IRS-1 serine hyperphosphorylation and restores insulin-triggered Akt activation in differentiated 3T3-L1 adipocytes. Cyclocarioside H enhances insulin-independent and insulin-mediated 2-NBDG glucose uptake to improve adipocyte insulin resistance under inflammatory stress. Cyclocarioside H can be used for research on inflammation-associated type 2 diabetes and insulin resistance. | |||||||||||||||||||||
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