2. Disease Areas
  3. Neurological, Eye or Ear Disease
  4. Neurodegenerative Disease
  5. Alzheimer's Disease
  6. AZD3676

AZD3676 is an orally active and blood-brain barrier-permeable ligand for 5-HT1A and 5-HT1B receptors, with nanomolar binding affinity for human and monkey receptors (human 5-HT1A: 0.16 nM, monkey 5-HT1A: 0.13 nM, human 5-HT1B: 2.3 nM, monkey 5-HT1B: 2.4 nM). AZD3676 is applicable to research related to cognitive impairment in Alzheimer's disease.

For research use only. We do not sell to patients.

AZD3676

AZD3676 Chemical Structure

CAS No. : 1259929-13-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

AZD3676 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZD3676 is an orally active and blood-brain barrier-permeable ligand for 5-HT1A and 5-HT1B receptors, with nanomolar binding affinity for human and monkey receptors (human 5-HT1A: 0.16 nM, monkey 5-HT1A: 0.13 nM, human 5-HT1B: 2.3 nM, monkey 5-HT1B: 2.4 nM). AZD3676 is applicable to research related to cognitive impairment in Alzheimer's disease[1].

In Vitro

AZD3676 (1 pM-100 nM (5-HT1A); 0.01 nM-1 μM (5-HT1B); 16 h, room temperature) exhibits nanomolar affinity for 5-HT1A (Ki = 0.13 nM) and 5-HT1B (Ki = 2.4 nM) receptors in cynomolgus monkey brain homogenates[1].
AZD3676 (0.4-20 μM; ~1 μM (predicted Cmax)) shows concentration-dependent plasma protein binding, with species-specific unbound fractions ranging from 0.014 (human) to 0.37 (guinea pig) at the predicted therapeutic maximum concentration of ~1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZD3676 Related Antibodies
Parmacokinetics
Species Dose Route CLplasma Vdss AUC0-inf Cmax T1/2 Bioavailability
Rat[1] 1 mg/kg i.v. 83 mL/min/kg 5.2 L/kg / / / /
Rat[1] 1 mg/kg i.v. 83 mL/min/kg 5.2 L/kg / / / /
Rat[1] 3 mg/kg p.o. / / 0.3 μM·h 0.40 μM 0.7 h 21 %
Rat[1] 3 mg/kg p.o. / / 0.3 μM·h 0.40 μM 0.7 h 21 %
Dog[1] 1 mg/kg i.v. 37 mL/min/kg 3.5 L/kg / / / /
Dog[1] 1 mg/kg i.v. 37 mL/min/kg 3.5 L/kg / / / /
Dog[1] 3 mg/kg p.o. / / 1.3 μM·h 2.6 μM 2.8 h /
Dog[1] 3 mg/kg p.o. / / 1.3 μM·h 2.6 μM 2.8 h /
In Vivo

AZD3676 (10 μmol/kg; s.c.; single dose) significantly reverses R-8-OH-DPAT-induced cognitive impairment in C57BL/6 mice, as demonstrated by restored freezing behavior in a contextual fear conditioning assay[1].
AZD3676 (1-10 μmol/kg; s.c., p.o.; single dose) significantly reverses Scopolamine(HY-N0296)-induced cognitive impairment in C57BL/6 mice, as demonstrated by restored freezing behavior in a contextual fear conditioning assay[1].
AZD3676 (0.03-3 μmol/kg; s.c.; single dose) dose-dependently occupies 5-HT1ₐ receptors in healthy C57BL/6 mice, with a half-maximum receptor occupancy of 0.05 μmol/kg s.c. in the frontal cortex[1].
AZD3676 (0.1-10 μmol/kg; s.c.; single dose) dose-dependently occupies 5-HT1A receptors in healthy Sprague Dawley rats, with a half-maximum receptor occupancy of 0.17 μmol/kg s.c. in the frontal cortex[1].
AZD3676 (0.3-10 μmol/kg; s.c.; single dose) dose-dependently occupies 5-HT1A and 5-HT1B receptors in healthy Dunkin Hartley guinea pigs, with half-maximum receptor occupancy values of 0.3 μmol/kg s.c. and 1.2 μmol/kg s.c., respectively[1].
AZD3676 (0.16-0.82 μmol/kg; i.v.; maintenance infusion following initial low-dose bolus) dose-dependently occupies 5-HT1A receptors in healthy cynomolgus monkeys, with a Ki,plasma of 84 nM for half-maximum occupancy in the prefrontal cortex[1].
AZD3676 (0.1-1.8 μmol/kg; i.v.; maintenance infusion following initial low-dose bolus) dose-dependently occupies 5-HT1B receptors in healthy cynomolgus monkeys, with a Ki,plasma of 72 nM for half-maximum occupancy in the occipital cortex[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6[1]
Dosage: 10 μmol/kg
Administration: s.c.; single dose
Result: Significantly reverted the R-8-OH-DPAT-induced memory deficit, as measured by increased freezing behavior relative to R-8-OH-DPAT-only treated mice.
Animal Model: C57BL/6[1]
Dosage: 3 μmol/kg; 10 μmol/kg; 1 μmol/kg
Administration: s.c.; single dose; p.o.; single dose
Result: Significantly reverted the scopolamine-induced memory deficit at 3 μmol/kg s.c., 10 μmol/kg s.c., and 1 μmol/kg p.o., as measured by increased freezing behavior relative to scopolamine-only treated mice.
Animal Model: C57BL/6[1]
Dosage: 0.03 μmol/kg; 0.1 μmol/kg; 0.3 μmol/kg; 1 μmol/kg; 3 μmol/kg
Administration: s.c.; single dose
Result: Dose-dependently occupied 5-HT1ₐ receptors in the mouse frontal cortex, with a half-maximum receptor occupancy of 0.05 μmol/kg s.c.
Animal Model: Sprague Dawley[1]
Dosage: 0.1 μmol/kg; 1 μmol/kg; 3 μmol/kg; 10 μmol/kg
Administration: s.c.; single dose
Result: Dose-dependently occupied 5-HT1ₐ receptors in the rat frontal cortex, with aa half-maximum receptor occupancy of 0.17 μmol/kg s.c.
Molecular Weight

378.48

Formula

C22H26N4O2
CAS No.
SMILES

O=C(C=1OC2=C(C=CC=C2N3CCN(CCC4=NC=CC=C4)CC3)C1)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AZD3676 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD36761259929-13-9AZD 3676AZD-3676rodent models5-HT1α receptor5-HT1β receptorC57BL/6 micecynomolgus monkey brain homogenatesDunkin Hartley guinea pigsAlzheimer’s diseaseSprague Dawley ratsnon-human primate braincynomolgus monkeysInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AZD3676
Cat. No.:
HY-122557
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.