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  4. C5 Lenalidomide

C5 Lenalidomide  (Synonyms: Lenalidomide 5'-amine)

製品番号: HY-132248 純度: 99.40%
COA 取扱説明書 Technical Support

C5 Lenalidomide is a 5-amino-substituted Thalidomide (HY-14658) analog. C5 Lenalidomide inhibits LPS (HY-D1056)-stimulated TNF-α production.

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C5 Lenalidomide

C5 Lenalidomide 構造式

CAS 番号 : 191732-70-4

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 77 在庫あり
Solution
10 mM * 1 mL in DMSO USD 77 在庫あり
Solid
50 mg $70 在庫あり
100 mg $110 在庫あり
250 mg $200 在庫あり
500 mg $280 在庫あり
1 g $400 在庫あり
5 g $1590 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

C5 Lenalidomide 関連抗体

Top Publications Citing Use of Products

TNF Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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製品説明

C5 Lenalidomide is a 5-amino-substituted Thalidomide (HY-14658) analog. C5 Lenalidomide inhibits LPS (HY-D1056)-stimulated TNF-α production[1].

IC50 & Target

Cereblon

 

Cellular Effect
Cell Line Type Value Description References
PBMC IC50
> 100 μM
Compound: Page no 420, R4C1, cpd 1
Antiinflammatory activity in human PBMC cells assessed as reduction in LPS-induced TNF-alpha production preincubated for 1 hr followed by LPS addition and measured after 18 to 20 hrs by ELISA
Antiinflammatory activity in human PBMC cells assessed as reduction in LPS-induced TNF-alpha production preincubated for 1 hr followed by LPS addition and measured after 18 to 20 hrs by ELISA
[PMID: 31125896]
体外実験

C5 Lenalidomide (Compound 8b) (100 μM) inhibits TNF-α production in LPS (HY-D1056)-stimulated human PBMC, and achieves 15% inhibition at 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C5 Lenalidomide 関連抗体
分子量

259.26

分子式

C13H13N3O3
CAS 番号
Appearance

Solid

Color

Gray to dark gray

SMILES

O=C(C(N(CC1=C2C=CC(N)=C1)C2=O)CC3)NC3=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (192.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8571 mL 19.2857 mL 38.5713 mL
5 mM 0.7714 mL 3.8571 mL 7.7143 mL
10 mM 0.3857 mL 1.9286 mL 3.8571 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
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純度とドキュメンテーション

純度: 99.62%

COA (247 KB) HNMR (134 KB) RP-HPLC (251 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8571 mL 19.2857 mL 38.5713 mL 96.4283 mL
5 mM 0.7714 mL 3.8571 mL 7.7143 mL 19.2857 mL
10 mM 0.3857 mL 1.9286 mL 3.8571 mL 9.6428 mL
15 mM 0.2571 mL 1.2857 mL 2.5714 mL 6.4286 mL
20 mM 0.1929 mL 0.9643 mL 1.9286 mL 4.8214 mL
25 mM 0.1543 mL 0.7714 mL 1.5429 mL 3.8571 mL
30 mM 0.1286 mL 0.6429 mL 1.2857 mL 3.2143 mL
40 mM 0.0964 mL 0.4821 mL 0.9643 mL 2.4107 mL
50 mM 0.0771 mL 0.3857 mL 0.7714 mL 1.9286 mL
60 mM 0.0643 mL 0.3214 mL 0.6429 mL 1.6071 mL
80 mM 0.0482 mL 0.2411 mL 0.4821 mL 1.2054 mL
100 mM 0.0386 mL 0.1929 mL 0.3857 mL 0.9643 mL
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C5 Lenalidomide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C5 Lenalidomide191732-70-4Lenalidomide 5'-amineDrug DerivativeTNF ReceptorDrug derivativeTumor Necrosis Factor ReceptorTNFRhuman peripheral blood mononuclear cellshuman PBMCTNF-αlipopolysaccharidetumor necrosis factor-alphaInhibitorinhibitorinhibit

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製品名:
C5 Lenalidomide
製品番号:
HY-132248
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