PTGER4 - prostaglandin E receptor 4 Gene

Also Known as EP4; EP4R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5734

About PTGER4

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,679,915-40,746,800 (from NCBI)

This gene has 5 transcripts (splice variants), 275 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 30.5), colon (RPKM 12.1) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

PTGER4 Products (1)

mRNA Protein Name
NM_000958.3 NP_000949.1 prostaglandin E2 receptor EP4 subtype

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables prostaglandin E receptor activity IDA
IDA: Inferred from direct assay
8078484 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16424369 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8078484 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
16204467 GOA
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8163486 GOA
involved in immune response IEP
IEP: Inferred from expression pattern
8862514 GOA
involved in negative regulation of eosinophil extravasation IDA
IDA: Inferred from direct assay
21681739 GOA
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
16424369 GOA
involved in negative regulation of integrin activation IDA
IDA: Inferred from direct assay
21681739 GOA
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
21723865 GOA
involved in response to prostaglandin E IDA
IDA: Inferred from direct assay
8163486 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
8163486 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGER4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (34 - 329)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

prostaglandin E2 receptor EP4 subtype

  • PGE receptor, EP4 subtype

Related Diseases

Diseases Alias
Basosquamous Carcinoma

  • Carcinoma, Basosquamous

  • Basisquamous Cell Carcinoma

  • Basosquamous Cell Carcinoma

  • Metatypical Carcinoma
Vulvar Sebaceous Carcinoma
Malignant Epithelial Mesothelioma

  • Epithelioid Mesothelioma, Malignant
Vulva Basal Cell Carcinoma

  • Basal Cell Carcinoma Of Vulva

  • Basal Cell Carcinoma Of The Vulva
Epididymis Adenocarcinoma

  • Adenocarcinoma Of The Epididymis
Epididymis Cancer

  • Malignant Tumor Of Epididymis

  • Malignant Epididymal Tumor

  • Malignant Neoplasm Of Epididymis

  • Neoplasm Of Epididymis
Metatypical Basal Cell Carcinoma

  • Skin Metatypical Carcinoma

  • Basosquamous Carcinoma Of Skin

  • Skin Metatypical Basal Cell Carcinoma
Papillary Thymic Adenocarcinoma

  • Papillary Carcinoma Of The Thymus
Fallopian Tube Serous Adenocarcinoma
Peritoneal Serous Papillary Adenocarcinoma

  • Primary Serous Papillary Carcinoma Of Peritoneum
Vulvar Eccrine Porocarcinoma
Lymphohistiocytoid Mesothelioma
Malignant Syringoma

  • Microcystic Adnexal Carcinoma

  • Microcystic Adnexal Carcinoma Of Skin

  • Syringomatous Carcinoma

  • Eccrine Epithelioma
Skin Amelanotic Melanoma

  • Skin Amelanotic Malignant Melanoma

  • Amelanotic Skin Melanoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Rete Testis Neoplasm
Rete Testis Adenocarcinoma

  • Adenocarcinoma Of Rete Testis

  • Adenocarcinoma Of The Rete Testis
Large Cell Acanthoma
Anus Basaloid Carcinoma

  • Basaloid Carcinoma Of The Anus

  • Anal Basaloid Carcinoma
Sarcomatoid Basal Cell Carcinoma

  • Skin Sarcomatoid Basal Cell Carcinoma
Inverted Follicular Keratosis

  • Inverted Folicular Keratosis

  • Seborrheic Keratosis
Peritoneal Serous Adenocarcinoma

  • Primary Peritoneal Serous Adenocarcinoma
Nodular Hidradenoma

  • Eccrine Nodular Hidradenoma

  • Eccrine Acrospiroma
Bartholin'S Gland Adenocarcinoma

  • Bartholin Gland Adenocarcinoma

  • Adenocarcinoma Of Bartholin'S Gland

  • Adenocarcinoma Of The Bartholin'S Gland
Pigmented Basal Cell Carcinoma

  • Skin Pigmented Basal Cell Carcinoma
Peritoneal Mesothelioma

  • Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Mesothelioma Of Peritoneum

  • Advanced Malignant Peritoneal Mesothelioma

  • Advanced Peritoneal Malignant Mesothelioma
Sarcomatoid Mesothelioma

  • Malignant Fibrous Mesothelioma

  • Spindled Mesothelioma
Penis Basal Cell Carcinoma

  • Basal Cell Carcinoma Of The Penis
Eccrine Sweat Gland Cancer

  • Malignant Eccrine Skin Neoplasm

  • Malignant Eccrine Tumor
Endosalpingiosis
Pericardial Mesothelioma

  • Malignant Mesothelioma Of Pericardium

  • Malignant Pericardial Mesothelioma
Peritoneum Cancer

  • Peritoneal Neoplasm

  • Cancer Of Peritoneum

  • Malignant Tumor Of Peritoneum

  • Peritoneal Neoplasms
Pericardium Cancer

  • Malignant Neoplasm Of Pericardium

  • Malignant Tumor Of Pericardium

  • Pericardial Tumor

  • Neoplasm Of Pericardium
Primary Hypertrophic Osteoarthropathy

  • Pachydermoperiostosis Syndrome

  • Osteoarthropathy, Primary Hypertrophic

  • Pachydermoperiostosis Of Nail

  • Idiopathic Hypertrophic Osteoarthropathy

  • Pho
Basaloid Squamous Cell Carcinoma

  • Basaloid Carcinoma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Benign Peritoneal Mesothelioma

  • Mesothelioma Of Peritoneum

  • Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Patent Ductus Arteriosus 1

  • Patent Ductus Arteriosus

  • PDA1

  • Pda

  • Ductus Arteriosus, Patent

  • Patent Ductus Arteriosus, Susceptibility To

  • Patent Ductus Botalli

  • Patency Of The Ductus Arteriosus

  • Patent Ductus Arteriosus Familial

  • Ductus Arteriosus Patent

  • Patent Ductus Arteriosus - Persisting Type
Comedo Carcinoma

  • Comedocarcinoma

  • High Grade Ductal Breast Carcinoma In Situ
Papillary Serous Adenocarcinoma

  • Micropapillary Serous Carcinoma

  • Serous Surface Papillary Carcinoma

  • Papillary Serous Carcinoma

  • Papillary Serous Cystadenocarcinoma
Squamous Papillomatosis
Borst-Jadassohn Intraepidermal Carcinoma

  • Intraepidermal Epithelioma Of Jadassohn

  • Bowen'S Disease, Clonal
Cystic Basal Cell Carcinoma

  • Skin Cystic Basal Cell Carcinoma
Muir-Torre Syndrome

  • MRTES

  • Keratoacanthoma

  • Muir-Torré Syndrome

  • Cutaneous Sebaceous Neoplasms And Keratoacanthomas, Multiple, With Gastrointestinal And Other Carcinomas

  • Cutaneous Sebaceous Neoplasms And Keratoacanthomas Multiple With Gastrointestinal And Other Carcinomas

  • Multiple Keratoacanthoma, Muir-Torre Type

  • Mts

  • Torre-Muir Syndrome
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Mesothelioma, Malignant

  • Malignant Mesothelioma

  • Pleural Mesothelioma

  • MESOM

  • Mesothelioma, Somatic

  • Advanced Malignant Mesothelioma

  • Asbestos-Related Malignant Mesothelioma

  • Diffuse Malignant Mesothelioma

  • Malignant Tumor Of Mesothelium

  • Malignant Mesothelioma, Susceptibility To

  • Mesothelioma Diffuse Malignant

  • Mesothelioma

  • Malignant Pleural Mesothelioma
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Basal Cell Carcinoma

  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11378 PTGER4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18874 Ptger4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25365 Ptger4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PTGER4 VGNC VGNC:45144
Macaca mulatta PTGER4 VGNC VGNC:76470
Rattus norvegicus PTGER4 RGD RGD:628641
Bos taurus PTGER4 VGNC VGNC:33504
Mus musculus PTGER4 MGD MGI:104311
Others PTGER4 NCBI