Homidium chloride
Homidium chloride is a potent antiparasitic agent exhibiting activity against Trypanosoma rhodesiense and Trypanosoma congolense. Homidium chloride can reduce parasitaemia in murine models of infection. Homidium chloride can be used for trypanosomiasis research.
For research use only. We do not sell to patients.
- CAS No.: 602-52-8
- Formula: C21H20ClN3
- Molecular Weight:349.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| L1210 | IC50 |
11 μM
Compound: Ethidium chloride
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Inhibition of incorporation of tritiated thymidine in the RNA of actively growing L1210 cells
Inhibition of incorporation of tritiated thymidine in the RNA of actively growing L1210 cells
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[PMID: 7310810] |
Homidium chloride (0.001-10 μg/mL; 6 h) eliminates the infectivity of T. congolense in vitro in citrate-saline at ≥ 0.1 μg/mL, but not in horse serum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice infected with T. rhodesiense and T. congolense[1]
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Dosage:75.0, 7.5, 0.75, 0.075 mg/kg
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Administration:i.p.; single dose
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Result:Exhibited antitrypanosomal activity against both T. rhodesiense and T. congolense.
Was approximately 12.5 times more active against T. congolense compared to T. rhodesiense.
Chemical Information
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CAS No. 602-52-8
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Molecular Weight 349.86
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Formula C21H20ClN3
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SMILES
NC1=CC2=C(C3=C([N+](CC)=C2C4=CC=CC=C4)C=C(N)C=C3)C=C1.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hill J. Studies on isometamidium: the effect of isometamidium, homidium and pyrithidium on the infectivity of trypanosomes for mice. Br J Pharmacol Chemother. 1965 Dec;25(3):658-63. [Content Brief]
[2]. Codjia V, et al. Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of populations of Trypanosoma congolense resistant to diminazene, isometamidium and homidium. Acta Trop. 1993 Apr;53(2):151-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Homidium chloride Related Classifications
HY-180418 Related Classifications
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