(2S,3R)-LP99
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion.
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- Pureté: 99.4%
- CAS No.: 1808948-28-8
- Formule: C26H30ClN3O4S
- Masse moléculaire:516.05
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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BRD7 |
BRD9 99 nM (Kd) |
(2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1808948-28-8
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Appearance Solid
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Masse moléculaire 516.05
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Formule C26H30ClN3O4S
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Color White to off-white
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SMILES
CC(CS(=O)(N[C@@H]([C@@H](N1C2=CC3=C(C(C)=CC(N3C)=O)C=C2)C4=CC=C(C=C4)Cl)CCC1=O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(2S,3R)-LP99 Related Classifications
HY-116227 Related Classifications
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