1808948-28-8
Chemical Structure
(2S,3R)-LP99
- CAS No.: 1808948-28-8
- Formula:C26H30ClN3O4S
- Molecular Weight:516.05
IUPAC Name: N-((2S,3R)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamide
InChIKey: LVDRREOUMKACNJ-GJZUVCINSA-N
SMILES: CC(CS(=O)(N[C@@H]([C@@H](N1C2=CC3=C(C(C)=CC(N3C)=O)C=C2)C4=CC=C(C=C4)Cl)CCC1=O)=O)C
Biological Activity: (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(2S,3R)-LP99 | 99.4% | (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion. | ||||||||||||||||||||
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Keywords
