6-Azathymine
Based on 1 Customer Validation
6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities.
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- Pureté: 99.94%
- CAS No.: 932-53-6
- Formule: C4H5N3O2
- Masse moléculaire:127.10
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 932-53-6
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Appearance Solid
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Masse moléculaire 127.10
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Formule C4H5N3O2
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Color White to off-white
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SMILES
O=C(N1)NN=C(C)C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 125 mg/mL (983.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. [Content Brief]
[2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14. [Content Brief]
[3]. R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.8678 mL | 39.3391 mL | 78.6782 mL | 196.6955 mL |
| 5 mM | 1.5736 mL | 7.8678 mL | 15.7356 mL | 39.3391 mL | |
| 10 mM | 0.7868 mL | 3.9339 mL | 7.8678 mL | 19.6696 mL | |
| 15 mM | 0.5245 mL | 2.6226 mL | 5.2452 mL | 13.1130 mL | |
| 20 mM | 0.3934 mL | 1.9670 mL | 3.9339 mL | 9.8348 mL | |
| 25 mM | 0.3147 mL | 1.5736 mL | 3.1471 mL | 7.8678 mL | |
| 30 mM | 0.2623 mL | 1.3113 mL | 2.6226 mL | 6.5565 mL | |
| 40 mM | 0.1967 mL | 0.9835 mL | 1.9670 mL | 4.9174 mL | |
| 50 mM | 0.1574 mL | 0.7868 mL | 1.5736 mL | 3.9339 mL | |
| 60 mM | 0.1311 mL | 0.6557 mL | 1.3113 mL | 3.2783 mL | |
| 80 mM | 0.0983 mL | 0.4917 mL | 0.9835 mL | 2.4587 mL | |
| 100 mM | 0.0787 mL | 0.3934 mL | 0.7868 mL | 1.9670 mL |
6-Azathymine Related Classifications
HY-136559 Related Classifications
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