Alizarin 2-methyl ether
Alizarin 2-methyl ether is a DNA topoisomerase inhibitor. Alizarin 2-methyl ether inhibits the relaxation of supercoiled DNA via DNA topoisomerase I and II. Alizarin 2-methyl ether promotes adipocyte differentiation by increasing lipid accumulation. Alizarin 2-methyl ether possesses antidiabetic and insulin-sensitizing properties. Alizarin 2-methyl ether can be used in research related to human colon cancer, P-388 lymphocytic leukemia and diabetes.
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- CAS No.: 6003-11-8
- Formule: C15H10O4
- Masse moléculaire:254.24
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Topoisomerase I |
Topoisomerase II |
Alizarin 2-methyl ether (compound 8) (20-100 μM; 30 min) inhibits calf thymus DNA topoisomerase I with 75% inhibition at 100 μM and 17% inhibition at 20 μM[1].
Alizarin 2-methyl ether (20-100 μM; 30 min) inhibits human DNA topoisomerase II with 49% inhibition at 100 μM and no inhibition at 20 μM[1].
Alizarin 2-methyl ether has no significant cytotoxicity to human breast carcinoma MCF-7 cells, with an IC50 greater than 100 μM[1].
Alizarin 2-methyl ether has no significant cytotoxicity to human liver carcinoma HepG2 cells, with an IC50 greater than 100 μM[1].
Alizarin 2-methyl ether is cytotoxic to human colon carcinoma HT-29 cells with an IC50 of 51.6 μM[1].
Alizarin 2-methyl ether (compound 2) (100 μM; 8 days) enhances adipocyte differentiation in 3T3-L1 mouse preadipocytes, increasing relative fat accumulation to 131% of insulin-treated control cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3-L1 mouse preadipocytes
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Concentration:100 μM
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Incubation Time:8 days
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Result:Enhanced adipocyte differentiation, resulting in a relative fat accumulation level of 131% compared to insulin-treated control cells.
Reached statistically significant effect relative to the insulin-treated control.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6003-11-8
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Masse moléculaire 254.24
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Formule C15H10O4
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SMILES
O=C1C2=C(C(C3=C(C(OC)=CC=C13)O)=O)C=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Son JK, et al. Anticancer constituents from the roots of Rubia cordifolia L. Chemical & pharmaceutical bulletin. 2008 Feb;56(2):213-6. [Content Brief]
[2]. Chang P, et al. Antitumor agents 50. 1 Morindaparvin-A, a new antileukemic anthraquinone, and alizarin-1-methyl ether from Morinda parvifolia, and the antileukemic activity of the related derivatives. J Nat Prod. 1982 Mar-Apr;45(2):206-10. [Content Brief]
[3]. Liu Q, et al. Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells. Nat Prod Res. 2012;26(18):1750-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Alizarin 2-methyl ether Related Classifications
HY-187153 Related Classifications
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