ALK/HDAC-IN-2
ALK/HDAC-IN-2 (Compound 19b) is an ALK/HDAC inhibitor with IC₅₀ values for ALK WT and total HDACs of 8 nM and 1.18 μM, respectively. ALK/HDAC-IN-2 exhibits inhibitory activity against ALK mutants G1202R, F1174L, and L1196M, with IC₅₀ values of 2.74, 9.23, and 34.28 nM, respectively. ALK/HDAC-IN-2 shows potent and selective inhibition against HDAC1 (IC₅₀ = 0.24 μM), while its inhibitory activity against HDAC7, HDAC6, and HDAC11 is weak (IC₅₀ > 10 μM). ALK/HDAC-IN-2 has broad-spectrum anti-proliferative activity against various cancer cells, inducing cell cycle arrest and apoptosis. ALK/HDAC-IN-2 can be used for the study of neuroblastoma.
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- Formule: C34H33ClN7O4P
- Masse moléculaire:670.10
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HDAC1 0.24 μM (IC50) |
HDAC7 > 10 μM (IC50) |
HDAC6 > 10 μM (IC50) |
HDAC11 > 10 μM (IC50) |
ALK G1202R 2.74 nM (IC50) |
ALK WT 8 nM (IC50) |
ALK F1174L 9.23 nM (IC50) |
ALK L1196M 34.28 nM (IC50) |
Chemical Information
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Masse moléculaire 670.10
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Formule C34H33ClN7O4P
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SMILES
NC1=C(NC(C2=CC=C(CNC(C3=CC=C(NC4=NC(NC5=CC=CC=C5P(C)(C)=O)=C(Cl)C=N4)C(OC)=C3)=O)C=C2)=O)C=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALK/HDAC-IN-2 Related Classifications
HY-180811 Related Classifications
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