Celivarone
Celivarone (SSR149744C) is a orally active noniodinated benzofuran derivative with antiarrhythmic properties. Celivarone has the potential for atrial fibrillation and in ventricular arrhythmias research.
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- CAS No.: 401925-43-7
- Formule: C34H47NO4
- Masse moléculaire:533.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Celivarone (SSR149744C) exhibits electrophysiological and hemodynamic properties of class I, II, III, and IV antiarrhythmic agents[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
At the ventricular level, Celivarone (0.1-10 mg/kg IV and 3-90 mg/kg PO) prevents reperfusion-induced arrhythmias in anesthetized rats with a dose-effect relationship, and, at doses of 30 to 90 mg/kg PO, it reduced early (0-24 hours) mortality following permanent left coronary artery ligature in conscious rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 401925-43-7
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Masse moléculaire 533.74
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Formule C34H47NO4
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SMILES
O=C(C1=CC2=C(OC(CCCC)=C2C(C3=CC=C(CCCN(CCCC)CCCC)C=C3)=O)C=C1)OC(C)C
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Synonyms
SSR149744C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Avinash R Khitri, et al. Celivarone for maintenance of sinus rhythm and conversion of atrial fibrillation/flutter. J Cardiovasc Electrophysiol. 2012 May;23(5):462-72. [Content Brief]
[2]. Patrick Gautier, et al. In vivo and in vitro antiarrhythmic effects of SSR149744C in animal models of atrial fibrillation and ventricular arrhythmias. J Cardiovasc Pharmacol. 2005 Feb;45(2):125-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Celivarone Related Classifications
HY-106207 Related Classifications
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