Cyanostatin B
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC50 = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC50 value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability..
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- CAS No.: 850131-23-6
- Formule: C40H59N5O9
- Masse moléculaire:753.92
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Cyanostatin B (0-75 μg/mL, 24 h) exhibits no toxicity to juveniles (nauplii) of the brine shrimp[1].
Cyanostatin B (0-10 μg/mL, 24-48 h) exhibits concentration-dependent inhibition of cell proliferation after 72 hours of exposure in HepG2 cells[2].
Cyanostatin B (0-1 μg/mL, 24-48 h) induces DNA single-strand breaks (SSBs) but not DNA double-strand breaks (DSBs) in HepG2 cells[2].
Cyanostatin B (1 μg/mL, 24-72 h) is clastogenic, causing chromosome breakage or loss of entire chromosomes in HepG2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 850131-23-6
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Masse moléculaire 753.92
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Formule C40H59N5O9
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sano T, et al. Leucine aminopeptidase M inhibitors, cyanostatin A and B, isolated from cyanobacterial water blooms in Scotland. Phytochemistry. 2005 Mar;66(5):543-8. [Content Brief]
[2]. Ujvárosi AZ, et al. The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line. Chemosphere. 2020 Feb;240:124880. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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