850131-23-6
Chemical Structure
Cyanostatin B
- CAS No.: 850131-23-6
- Formula:C40H59N5O9
- Molecular Weight:753.92
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@@H](O)[C@H](N)CCCCCCC)=O)C(N(C)[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)CC3=CC=C(C=C3)O)=O)=O)=O
Biological Activity: Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC50 = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC50 value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability.[1][2].
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Cyanostatin B | Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC50 = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC50 value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability.. | |||||||||||||||||||||
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- [1]. Sano T, et al. Leucine aminopeptidase M inhibitors, cyanostatin A and B, isolated from cyanobacterial water blooms in Scotland. Phytochemistry. 2005 Mar;66(5):543-8. [Content Brief]
- [2]. Ujvárosi AZ, et al. The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line. Chemosphere. 2020 Feb;240:124880. [Content Brief]
Keywords
