DFCI-002-06
DFCI-002-06 is an orally active dual-target HCK/BTK PROTAC degrader with DC₅₀ values for HCK and BTK of 1.3 and 4.5 nM respectively. DFCI-002-06 retains higher anti-tumor activity than the HCK/BTK dual-target inhibitor (HY-15805), inducing apoptosis in cancer cells. DFCI-002-06 can be used for the study of MYD88 mutant B-cell malignancies.
(Pink: Src and Btk ligand (HY-15805); Blue: Cereblon ligand (HY-W087383); Black: linker).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3092208-36-8
- Formule: C44H46N10O5
- Masse moléculaire:794.90
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Hck 1.3 nM (DC50) |
Cereblon |
Chemical Information
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CAS No. 3092208-36-8
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Masse moléculaire 794.90
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Formule C44H46N10O5
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SMILES
NC1=C2C(N([C@@H]3CC[C@@H](N4CCN(CC5CN(C6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)C5)CC4)CC3)N=C2C9=CC=C(OC%10=CC=CC=C%10)C=C9)=NC=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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