3092208-36-8
Chemical Structure
DFCI-002-06
- CAS No.: 3092208-36-8
- Formula:C44H46N10O5
- Molecular Weight:794.90
InChIKey: MSDFCFUNLHSPFM-DJYSDWLISA-N
SMILES: NC1=C2C(N([C@@H]3CC[C@@H](N4CCN(CC5CN(C6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)C5)CC4)CC3)N=C2C9=CC=C(OC%10=CC=CC=C%10)C=C9)=NC=N1
Biological Activity: DFCI-002-06 is an orally active dual-target HCK/BTK PROTAC degrader with DC₅₀ values for HCK and BTK of 1.3 and 4.5 nM respectively. DFCI-002-06 retains higher anti-tumor activity than the HCK/BTK dual-target inhibitor (HY-15805), inducing apoptosis in cancer cells. DFCI-002-06 can be used for the study of MYD88 mutant B-cell malignancies[1].
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DFCI-002-06 | DFCI-002-06 is an orally active dual-target HCK/BTK PROTAC degrader with DC₅₀ values for HCK and BTK of 1.3 and 4.5 nM respectively. DFCI-002-06 retains higher anti-tumor activity than the HCK/BTK dual-target inhibitor (HY-15805), inducing apoptosis in cancer cells. DFCI-002-06 can be used for the study of MYD88 mutant B-cell malignancies. | |||||||||||||||||||||
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Keywords
