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Cat. No.: HY-W842297

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Epiquinine

Epiquinine is a stereoisomer of Quinine (HY-D0143). Epiquinine exhibits activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum parasites. Epiquinine can be used for the research of malaria.

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CAS No.: 572-60-1
Formule: C₂₀H₂₄N₂O₂
Masse moléculaire:324.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

Epiquinine Chemical Structure

CAS No.: 572-60-1

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Description

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In Vitro

Epiquinine shows weak antimalarial activity, with an IC₅₀ of 3471.0 nM against chloroquine-sensitive Plasmodium falciparum D-6 clone and an IC₅₀ of 1179.0 nM against chloroquine-resistant Plasmodium falciparum W-2 clone^[1].
Epiquinine (100 µM; 30 min) inhibits haem association with human erythrocyte ghost membranes, reducing membrane-bound haem levels to approximately 25% of the total haem in the assay^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 572-60-1
Masse moléculaire 324.42
Formule C₂₀H₂₄N₂O₂
SMILES

[C@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@]3([N@@]4C[C@H](C=C)[C@](C3)(CC4)[H])[H]
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Karle JM, et al. Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity. Bioorg Med Chem. 1999;7(9):1769-1774. [Content Brief]

[2]. Loria P, et al. Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials. Biochem J. 1999;339 ( Pt 2)(Pt 2):363-370. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Epiquinine

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Epiquinine Related Classifications

HY-W842297 Related Classifications