572-60-1
572-60-1
Chemical Structure
Epiquinine
- CAS No.: 572-60-1
- Formula:C20H24N2O2
- Molecular Weight:324.42
IUPAC Name: (S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol
InChIKey: LOUPRKONTZGTKE-FEBSWUBLSA-N
SMILES: [C@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@]3([N@@]4C[C@H](C=C)[C@](C3)(CC4)[H])[H]
Biological Activity: Epiquinine is a stereoisomer of Quinine (HY-D0143). Epiquinine exhibits activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum parasites. Epiquinine can be used for the research of malaria[1][2].
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Epiquinine | Epiquinine is a stereoisomer of Quinine (HY-D0143). Epiquinine exhibits activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum parasites. Epiquinine can be used for the research of malaria. | |||||||||||||||||||||
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References
- [1]. Karle JM, et al. Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity. Bioorg Med Chem. 1999;7(9):1769-1774. [Content Brief]
- [2]. Loria P, et al. Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials. Biochem J. 1999;339 ( Pt 2)(Pt 2):363-370. [Content Brief]
Keywords
