SLC37A4 - solute carrier family 37 member 4 Gene

Also Known as G6PT; SPX4; CDG2W; G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2542

About SLC37A4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,024,112-119,030,877 (from NCBI)

This gene has 27 transcripts (splice variants), 1 gene allele, 277 orthologues, 12 paralogues and is associated with 6 phenotypes. Broad expression in kidney (RPKM 40.6), duodenum (RPKM 31.3) and 24 other tissues.

Summary

This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]

SLC37A4 Products (5)

mRNA	Protein	Name
NM_001164277.2	NP_001157749.1	glucose-6-phosphate exchanger SLC37A4 isoform 1
NM_001164278.2	NP_001157750.1	glucose-6-phosphate exchanger SLC37A4 isoform 2
NM_001164279.2	NP_001157751.1	glucose-6-phosphate exchanger SLC37A4 isoform 3
NM_001164280.2	NP_001157752.1	glucose-6-phosphate exchanger SLC37A4 isoform 1
NM_001467.6	NP_001458.1	glucose-6-phosphate exchanger SLC37A4 isoform 1

SLC37A4 Protein Structure

MFS_1

0
100
200
300
400
429 a.a.

Protein Preferred Names	Protein Names
glucose-6-phosphate exchanger SLC37A4	glucose-5-phosphate transporter

SLC37A4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SLC37A4	O43826	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	SLC37A4	O43826	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	SLC37A4	O43826	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Glycogen Storage Disease Ib	Glucose-6-Phosphate Transport Defect GSD1B Gsd Ib Glycogen Storage Disease Type 1b Glycogen Storage Disease 1b Gsd-Ib Glycogen Storage Disease, Type Ib
Glycogen Storage Disease Ic	GSD1C Gsd Ic Glycogen Storage Disease Type 1c Glycogen Storage Disease 1c Gsd-Ic Glycogen Storage Disease 1d GSD1D Glycogen Storage Disease Id Gsd-Id Glycogen Storage Disease, Type Ic Glycogen Storage Disease Type Id
Congenital Disorder Of Glycosylation, Type Iiw	CDG2W Congenital Disorder Of Glycosylation 2w
Glucose-6-Phosphate Translocase Deficiency	G6p Translocase Deficiency
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib	G6p Deficiency Type Ib G6p Translocase Deficiency G6pt Deficiency Gsd Due To G6p Deficiency Type 1b Gsd Due To G6p Deficiency Type Ib Gsd Due To G6pt Deficiency Gsd Type 1 Non A Gsd Type 1b Gsd Type Ib Gsdib Glycogen Storage Disease Due To G6p Deficiency Type Ib Glycogen Storage Disease Type 1b Glycogen Storage Disease Type Ib Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1b Glycogenosis Due To Glucose-6-Phosphatase Transport Defect Type Ib Glycogenosis Type 1b Glycogenosis Type Ib
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Neutropenia	Leukopenia
Glycogen Storage Disease Ia	Von Gierke Disease Glycogen Storage Disease Type I Glycogen Storage Disease I Hepatorenal Form Of Glycogen Storage Disease Hepatorenal Glycogenosis Glucose-6-Phosphatase Deficiency Glycogen Storage Disease, Type I Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia GSD1A Gsd1 Von Gierke'S Disease Glycogen Storage Disease Type 1a Glycogen Storage Disease 1a Glucose-6-Phosphate Transport Defect Gsd Ia Deficiency Of Glucose-6-Phosphatase Glycogenosis Type I Glucose-6-Phosphatase Deficiency Glycogen Storage Disease Glycogenosis Type 1 Glucose-6-Phosphate Deficiency Gsd I Gsd Type I G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type Ia Gsd Type 1a Gsdia Glycogen Storage Disease Due To G6p Deficiency Type Ia Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia Glycogenosis Type Ia Gsd-Ia Storage Disease, Glycogen, Type 1a Glycogen Storage Disease Type Ia
Splenomegaly
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Hepatocellular Adenoma	Adenoma Hepatocellular
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Hyperuricemia	Blood Urate Raized Uricacidemia
Glycogen Storage Disease Iii	Glycogen Storage Disease Type Iii Forbes Disease Cori Disease Glycogen Storage Disease Iiia Amylo-1,6-Glucosidase Deficiency Glycogen Storage Disease Iiib Limit Dextrinosis GSD3 Agl Deficiency Glycogen Debrancher Deficiency Gde Deficiency Glycogen Storage Disease Iiic Debrancher Deficiency Glycogen Storage Disease Type 3 Glycogenosis Type Iii Glycogen Storage Disease Iiid Amylo 1,6 Glucosidase Deficiency Deficiency Of Debranching Enzyme Deficiency Of Dextrin Glycogen Storage Disease, Type Iii Glycogen Debranching Enzyme Deficiency Cori'S Disease Gsd Iii Glycogen Storage Disease Due To Glycogen Debranching Enzyme Deficiency Cori-Forbes Disease Gsd Due To Glycogen Debranching Enzyme Deficiency Gsd Type 3 Gsdiii Glycogenosis Due To Glycogen Debranching Enzyme Deficiency Glycogenosis Type 3 Glycogen Storage Disease 3 Glycogen Debranching Enzyme Deficiency Gsd-Iii Gsd Iiia Gsd Iiib Gsd Iiic Gsd Iiid Storage Disease, Glycogen, Type Iii
Severe Congenital Neutropenia 4	Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency Scn4 Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome Dursun Syndrome Severe Congenital Neutropenia Type 4
Severe Congenital Neutropenia 3	Kostmann Syndrome Infantile Agranulocytosis Kostmann Disease Scn3 Severe Congenital Neutropenia Type 3
Liver Benign Neoplasm	Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Cyclic Neutropenia	Cyclic Hematopoiesis Cyclical Neutropenia Neutropenia Cyclic Cyclic Hematopoesis Neutropenia, Cyclic Cyclic Agranulocytosis Neutropenia, Periodic Cyclic Leucopenia Periodic Neutropenia Cyclic Haematopoiesis CH Hematopoiesis, Cyclic Neutropenia, Cyclical
Severe Congenital Neutropenia 5	Congenital Neutropenia-Myelofibrosis-Nephromegaly Syndrome Congenital Neutropenia-Bone Marrow Fibrosis-Nephromegaly Syndrome Vps45 Deficiency Scn5
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Glycerol Kinase Deficiency	Hyperglycerolemia GKD Gk Deficiency Gk1 Deficiency Deficiency Of Glycerol Kinase Isolated Glycerol Kinase Deficiency Glycerol Kinase Deficiency, Adult Form Glycerol Kinase Deficiency, Juvenile Form Deficiency, Glycerol Kinase
Autosomal Dominant Severe Congenital Neutropenia	Severe Congenital Neutropenia Autosomal Dominant Neutropenia, Congenital, Severe, Autosomal Dominant
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS13216	SLC37A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21257	Slc37a4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27776	Slc37a4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC37A4	RGD	RGD:62066
Felis catus	SLC37A4	VGNC	VGNC:65341
Mus musculus	SLC37A4	MGD	MGI:1316650
Canis familiaris	SLC37A4	VGNC	VGNC:46389
Bos taurus	SLC37A4	VGNC	VGNC:34845
Macaca mulatta	SLC37A4	VGNC	VGNC:77591
Others	SLC37A4	NCBI