Ncor1 - nuclear receptor co-repressor 1 Gene

Also Known as Rxrip13

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54299

Summary

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in animal organ development; negative regulation of macromolecule metabolic process; and positive regulation of cell population proliferation. Located in nucleus and perinuclear region of cytoplasm. Used to study anxiety disorder and polycystic ovary syndrome. Biomarker of hypothyroidism and polycystic ovary syndrome. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncor1 Products (1)

mRNA Protein Name
NM_001271103.1 NP_001258032.1 nuclear receptor corepressor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17079677 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
20352046 RGD
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
17079677 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
19460436 RGD
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
15234273 RGD
enables nuclear retinoid X receptor binding IPI
IPI: Inferred from physical interaction
15234273 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
15870285 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10441327 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10441327 RGD
Biological Process GO Annotation Evidence Références Source
involved in cerebellum development IEP
IEP: Inferred from expression pattern
10803578 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
15946693 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9139820 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19608741 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19608741 RGD
involved in skeletal muscle tissue development IEP
IEP: Inferred from expression pattern
9839950 RGD
Cellular Component GO Annotation Evidence Références Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19696011 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor corepressor 1

  • N-CoR

  • N-CoR1

  • N-Cor/SMRT corepressor, Rip13

  • NCoR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-121900 LT175 Agonist 99.46% Unkown
HY-176851 GSK1362 Inhibitor 96.38% Unkown
HY-177756 BCL6-IN-11 Inhibitor / Unkown
HY-RS09096 NCOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20452 Ncor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26961 Ncor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncor1 NCBI NCBI:9611