Tfam - transcription factor A, mitochondrial Gene

Also Known as Mttfa

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83474

Summary

Enables heat shock protein binding activity and transcription coactivator binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and transcription initiation from mitochondrial promoter. Predicted to act upstream of or within mitochondrial respiratory chain complex assembly. Located in mitochondrion. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

Tfam Products (1)

mRNA Protein Name
NM_031326.2 NP_112616.2 transcription factor A, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
22003111 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
23297307 RGD
Biological Process GO Annotation Evidence Références Source
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
33310031 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
33310031 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor A, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-W011725 N-6-Methyl-2-deoxyadenosine Inhibitor 99.83% Unkown
HY-175739 TFAM activator 1 99.25% Unkown
HY-RS14407 TFAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3225 Myricanol 98.93% Unkown
HY-RS17056 Tfam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23500 Tfam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfam NCBI NCBI:7019