CCNT2 - cyclin T2 Gene

Also Known as CYCT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 905

About CCNT2

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:134,918,822-134,959,342 (from NCBI)

This gene has 10 transcripts (splice variants), 293 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

CCNT2 Products (4)

mRNA Protein Name
NM_001241.4 NP_001232.1 cyclin-T2 isoform a
NM_001320748.2 NP_001307677.1 cyclin-T2 isoform d
NM_001320749.2 NP_001307678.1 cyclin-T2 isoform e
NM_058241.3 NP_490595.1 cyclin-T2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables 7SK snRNA binding IDA
IDA: Inferred from direct assay
11713533 GOA
enables RNA polymerase binding IPI
IPI: Inferred from physical interaction
15563843 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9499409 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16331689 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
12037672 GOA
Biological Process GO Annotation Evidence Références Source
involved in early viral transcription IDA
IDA: Inferred from direct assay
21509660 GOA
involved in late viral transcription IDA
IDA: Inferred from direct assay
21509660 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15563843 GOA
involved in positive regulation of transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
9499409 GOA
involved in regulation of muscle cell differentiation IDA
IDA: Inferred from direct assay
16331689 GOA
Cellular Component GO Annotation Evidence Références Source
part of cyclin/CDK positive transcription elongation factor complex IDA
IDA: Inferred from direct assay
9499409 GOA
part of cyclin/CDK positive transcription elongation factor complex IPI
IPI: Inferred from physical interaction
9499409 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9499409 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNT2 Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (11 - 147)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

cyclin-T2

  • SDS-stable vimentin-bound DNA fragment HEF42VIM22

CCNT2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P89818 cyclin T2a/b Antibody (YA9162) WB, IP human

Related Diseases

Diseases Alias
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02142 CCNT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21507 Ccnt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28025 Ccnt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CCNT2 VGNC VGNC:38907
Rattus norvegicus CCNT2 RGD RGD:1309205
Felis catus CCNT2 VGNC VGNC:60568
Macaca mulatta CCNT2 VGNC VGNC:70736
Bos taurus CCNT2 VGNC VGNC:26979
Mus musculus CCNT2 MGD MGI:1920199
Others CCNT2 NCBI