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Cat. No.: HY-19252

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GR-4991W93

GR-4991W93 is an orally active partial agonist against 5HT_1B/1D receptor, with pIC₅₀ values of 6.95 and 7.80 against 5HT_1B and 5HT_1D, respectively. GR-4991W93 demonstrates potent inhibition of electrically evoked plasma extravasation in the guinea pig. GR-4991W93 can be used for migraine research.

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CAS No.: 171549-56-7
Formule: C₁₈H₂₃N₃O₂
Masse moléculaire:313.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

GR-4991W93 Chemical Structure

CAS No.: 171549-56-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

5-HT_1B Receptor

6.95 (pIC₅₀)

5-HT_1D Receptor

7.80 (pIC₅₀)

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Chemical Information

CAS No. 171549-56-7
Masse moléculaire 313.39
Formule C₁₈H₂₃N₃O₂
SMILES

CN(C)[C@H](C1)C[C@@H]1C2=CNC3=CC=C(C[C@@H]4NC(OC4)=O)C=C32
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jandu KS, et al. Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem. 2001 Mar 1;44(5):681-93. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
Pureté et documentation
Références

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GR-4991W93

Voir tous les produits spécifiques à Isoform 5-HT Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

GR-4991W93 Related Classifications

HY-19252 Related Classifications