His-TERRα
His-TERRα is a ERRα PROTAC degrader. His-TERRα uses a single amino acid (His) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, and thus is called a mini-PROTAC. His-TERRα significantly inhibits the proliferation and migration of MCF7 breast cancer cells. His-TERRα can be used for the study of breast cancer.
(Pink: ERRα Target protein ligand; Blue: Ligands for E3 Ligase ligand (HY-N0832); Black: linker).
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- CAS No.: 2408835-49-2
- Formule: C31H28F3N9O5S
- Masse moléculaire:695.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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ERRα |
Chemical Information
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CAS No. 2408835-49-2
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Masse moléculaire 695.67
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Formule C31H28F3N9O5S
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SMILES
FC(F)(F)C(C=C(C=C1)C#N)=C1OC2=C(C=C(C=C2)/C=C3C(N(C(S\3)=O)CC4=CN(N=N4)CCCNC([C@@H](N)CC5=CN=CN5)=O)=O)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
His-TERRα Related Classifications
HY-180961 Related Classifications
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