Cat. No.: HY-W153897

N-Methyltyramine

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N-Methyltyramine is an orally active α2-adrenoreceptor antagonist with an IC₅₀ value of 5.53 μM against rat targets. N-Methyltyramine blocks α2-adrenoreceptors, while inhibiting lipolysis, hyperactivity responses and small intestinal peristalsis in mice. N-Methyltyramine promotes gastrin release and pancreatic juice secretion, upregulates appetite, blood pressure, myocardial contraction frequency and contraction intensity, and increases renal blood flow, renal vascular resistance and mean peripheral arterial resistance. N-Methyltyramine relaxes mouse small intestinal smooth muscle and undergoes biotransformation in vivo to produce adrenaline. N-Methyltyramine can be used in studies related to gastrointestinal diseases.

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Pureté: 99.83%
CAS No.: 370-98-9
Formule: C₉H₁₃NO
Masse moléculaire:151.21

Stockage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

N-Methyltyramine Chemical Structure

CAS No.: 370-98-9

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Adrenergic Receptor :

In Vitro

N-Methyltyramine mildly inhibits lipolysis in isolated rat and human adipocytes in vitro^[1].
N-Methyltyramine inhibits the binding of [³H]-para-amino Clonidine (HY-12721) to α₂-adrenergic receptors in crude synaptosomal membranes from rat brain, with an IC₅₀ of 5.53 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

N-Methyltyramine maximally stimulates gastrin release in rats at a dose of 25 μg/kg, with an ED₅₀ of approximately 10 μg/mL^[1].
N-Methyltyramine (infused into stomach) dose-dependently stimulates pancreatic secretion in rats when infused into the stomach, with beer-derived NMT capable of driving greater than 50% secretion^[1].
N-Methyltyramine administered intravenously at 0.04 mg/kg/min increases renal hemodynamic parameters and mean arterial pressure in dogs, while a 0.25 mg/kg i.v. bolus markedly elevates peripheral resistance^[1].
Radio-labeled N-Methyltyramine (i.v.; single dose) distributes rapidly to all organs (with highest levels in liver and kidneys) and is rapidly excreted and metabolized in rabbits and mice following intravenous administration^[1].
N-methyltyramine (20-100 mg/kg; i.p.; single dose) acts as an α₂-adrenoceptor antagonist, dose-dependently inhibiting scopolamine (HY-N0296)-induced hypermotility in male ddY mice^[2].
N-Methyltyramine (3-30 mg/kg; p.o.; single dose) dose-dependently inhibits mouse small intestinal propulsive function, with significant effects observed at 3 mg/kg, 9 mg/kg, and 30 mg/kg via oral administration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 370-98-9
Appearance Solid
Masse moléculaire 151.21
Formule C₉H₁₃NO
Color White to off-white
SMILES

CNCCC1=CC=C(C=C1)O
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (661.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.6133 mL

33.0666 mL

66.1332 mL

5 mM

1.3227 mL

6.6133 mL

13.2266 mL

10 mM

0.6613 mL

3.3067 mL

6.6133 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Stohs SJ. A Review of the Receptor Binding and Pharmacological Effects of N-methyltyramine. Phytotherapy Research. 2014;29(1):14-16. [Content Brief]

[2]. Koda H, et al. Antagonistic Effect of N-Methyltyramine on α₂-Adrenoceptor in Mice. Jpn J Pharmacol. 1999;81:313-315.

[3]. Ni J, et al. Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders. Biomedicine & Pharmacotherapy. 2019;111:1393-1398. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.6133 mL	33.0666 mL	66.1332 mL	165.3330 mL
	5 mM	1.3227 mL	6.6133 mL	13.2266 mL	33.0666 mL
	10 mM	0.6613 mL	3.3067 mL	6.6133 mL	16.5333 mL
	15 mM	0.4409 mL	2.2044 mL	4.4089 mL	11.0222 mL
	20 mM	0.3307 mL	1.6533 mL	3.3067 mL	8.2666 mL
	25 mM	0.2645 mL	1.3227 mL	2.6453 mL	6.6133 mL
	30 mM	0.2204 mL	1.1022 mL	2.2044 mL	5.5111 mL
	40 mM	0.1653 mL	0.8267 mL	1.6533 mL	4.1333 mL
	50 mM	0.1323 mL	0.6613 mL	1.3227 mL	3.3067 mL
	60 mM	0.1102 mL	0.5511 mL	1.1022 mL	2.7555 mL
	80 mM	0.0827 mL	0.4133 mL	0.8267 mL	2.0667 mL
	100 mM	0.0661 mL	0.3307 mL	0.6613 mL	1.6533 mL

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N-Methyltyramine

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Voir tous les produits spécifiques à Isoform Adrenergic Receptor

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

N-Methyltyramine Related Classifications

HY-W153897 Related Classifications