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Cat. No.: HY-151103

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Neuraminidase-IN-10

Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with anti-influenza activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC₅₀ values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively.

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CAS No.: 2685786-29-0
Formule: C₂₆H₃₄N₂O₅S
Masse moléculaire:486.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Neuraminidase-IN-10 Chemical Structure

CAS No.: 2685786-29-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	CC₅₀	>250 μM Compound: 12e	Cytotoxicity against chick embryo fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against chick embryo fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 35939763]
MDCK	CC₅₀	>250 μM Compound: 12e	Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 35939763]

In Vitro

Neuraminidase-IN-10 displays promising anti-influenza virus activity with EC₅₀ value of 7.28 and 0.71μM for H5N1 and H5N8, respectively in CEFs. Neuraminidase-IN-10 displays anti-influenza virus activity with EC₅₀ values of 0.04 ± 0.04 and 28.70 ± 1.61 μM, respectively in MDCK Cells^[1].
Metabolic stability is an important indicator for the assessment of drug candidates. Neuraminidase-IN-10 exhibits a T_1/2 (min), CL_int(mic) (μL/min/kg), CL_{int (liver)} (mL/min/kg) and remaining (T=60 min)(%) values of 120.5 min, 11.5 μL/min/kg, 10.4 mL/min/kg and 73.8 mins, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SPF Chicken Embryonated Egg^[1]
Dosage:

0.156 mM; 0.625 mM; 2.5 mM; 10 mM
Administration:

Injected into the egg
Result:

were not as effective as OSC in this infection model, but also exhibited a certain therapeutic effect.
The survival rates of Neuraminidase-IN-10 (H5N1: 100 and 40%, respectively; H5N8: 100 and 100%, respectively) at 2.5 mM and 10 mM^[1].

Chemical Information

CAS No. 2685786-29-0
Masse moléculaire 486.62
Formule C₂₆H₃₄N₂O₅S
SMILES

O=C(C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](NCC2=CC=C(C3=CC=CS3)C=C2OC)C1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Han Ju, et al. Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity. J Med Chem. 2022 Aug 8. doi: 10.1021/acs.jmedchem.1c01970. [Content Brief]

Calculators

Calculateur de molarité

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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