Neuraminidase-IN-18
Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC50 of 0.14 μM and 0.27 μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level.
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- CAS No.: 2935407-32-0
- Formule: C22H18FN3O3S
- Masse moléculaire:423.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Neuraminidase-IN-18 (compound N5) shows the EC50 value of 3.70 μM in vitro antiviral activities against H5N1 by CCK-8 method[1].
The aromatic fused rings and 1,3,4-oxadiazole rings in Neuraminidase-IN-18 are well embedded in the active sites. Neuraminidase-IN-18 can form strong hydrogen-bonding interactions with the three positively charged key arginine residues (Arg118, Arg292, and Arg371) at the active site[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2935407-32-0
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Masse moléculaire 423.46
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Formule C22H18FN3O3S
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SMILES
O=C(CSC1=NN=C(COC2=CC3=C(C=CC=C3)C=C2)O1)NCC4=CC=C(C=C4)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuraminidase-IN-18 Related Classifications
HY-163393 Related Classifications
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