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Cat. No.: HY-161351

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STAT3/AKT-IN-1

STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells.

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Formule: C₂₃H₂₂O₄
Masse moléculaire:362.42

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

STAT3/AKT-IN-1 Chemical Structure

Stock

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Stat-3

Voir tous les produits spécifiques à Isoform Akt :

Voir tous les produits spécifiques à Isoform STAT :

In Vitro

STAT3/AKT-IN-1 inihibits cell viability of gastric cancer cells SGC-7901 and BGC-823 with IC₅₀s of 1.39 μM and 2.92 μM, respectively^[1].
STAT3/AKT-IN-1 (2.5-10 μM) inhibits proliferation and migration, induces apoptosis by triggering cell cycle arrest at G2/M phase in SGC-7901 in a dose-dependent manner^[1]. Migration assay^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

SGC-7901
Concentration:

2.5-10 μM
Incubation Time:

48 h
Result:

Inhibited migration of SGC-7901 cells.

Cell Cycle Analysis^[1]

Cell Line:

SGC-7901
Concentration:

2.5-10 μM
Incubation Time:

48 h
Result:

Arrested cell cycle at G2/M phase.

Western Blot Analysis^[1]

Cell Line:

SGC-7901
Concentration:

2.5-10 μM
Incubation Time:

18 h
Result:

Inhibited phosphorylation of AKT (Ser473) and STAT3 (Tyr705).

In Vivo

STAT3/AKT-IN-1 (15 mg/kg, i.p., daily for 20 days) exhibits anticancer activity without significant toxicity in SGC-7901 xenografted BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SGC-7901 xenografted BALB/c mice^[1]
Dosage:

15 mg/kg
Administration:

i.p. once daily for 20 days
Result:

Inhibited tumor growth without weight loss.

Chemical Information

Masse moléculaire 362.42
Formule C₂₃H₂₂O₄
SMILES

O=C1/C(CC/C1=C\C=C\C2=CC=CC=C2OC)=C/C3=CC=C(O)C(OC)=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gan X, et al., Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an o-methoxy phenyl group as potential agents against gastric cancer. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2314233. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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STAT3/AKT-IN-1

Voir tous les produits spécifiques à Isoform Akt

Voir tous les produits spécifiques à Isoform STAT