STING-IN-18
STING-IN-18 is an orally active STING inhibitor. STING-IN-18 exhibits an IC50 of 86 nM against STING in murine RAW-LuciaTM ISG cells. STING-IN-18 inhibits STING activation and blocks downstream signaling pathways. STING-IN-18 suppresses kidney injury and inflammation. STING-IN-18 can be used for the research of autoimmune and inflammatory diseases.
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- Formule: C18H18FN5O
- Masse moléculaire:339.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
STING-IN-18 (Compound QQ21) (1-5 μM; 14 h) inhibits the downstream signaling pathway of STING in RAW264.7 and THP-1 cells, and reduces the levels of IFNβ, TNFα, IL6 and CXCL10[1].
STING-IN-18 (2.5-5 μM; 24 h) reduces Cisplatin (HY-17394)-induced ROS production in THP-1 cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 and THP-1
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Concentration:1 and 5 μM
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Incubation Time:Pretreated for 2 h, and treated with MSA-2 (HY-136927) for 14 h.
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Result:Inhibited the mRNA levels of FNβ, TNFα, IL6, and CXCL10 in a dose-dependent manner.
STING-IN-18 (10 mg/kg; i.p.; 4 days) effectively alleviates Cisplatin (HY-17394)-induced acute kidney injury in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J (male, 8 weeks old, acute kidney injury model induced by Cisplatin (HY-17394) )[1]
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Dosage:10 mg/kg
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Administration:i.p.; daily; 4 days
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Result:Alleviated kidney enlargement and ischemic symptoms. Reduced elevated blood urea nitrogen (BUN) and serum creatinine levels.
Inhibited cisplatin-induced upregulation of IFNβ and TNFα protein levels.
Mitigated renal injury observed via H&E staining.
Chemical Information
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Masse moléculaire 339.37
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Formule C18H18FN5O
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SMILES
FC1=CC=C2C(C(NC(C3=NC=C(NC4CCCC4)N=C3)=O)=CN2)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STING-IN-18 Related Classifications
HY-181057 Related Classifications
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