ZZ7-23-022
ZZ7-23-022 (ZZ7) is a selective BRD9 molecule glue degrader. ZZ7-23-022 effectively degrades BRD9 in synovial sarcoma cells, but does not affect cardiomyocytes. ZZ7-23-022 can be used for the research of cancer.
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- Formule: C36H45N7O5
- Masse moléculaire:655.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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BRD9 |
ZZ7-23-022 (0.1-3 μM, 5 h) degrades BRD9 in a dose-dependent manner in Jurkat cells[1].
ZZ7 (0.05-0.5 μM, 5 h) effectively degrades BRD9 in synovial sarcoma cells (CME-1, HS-SY-II, 1273/99), but does not affect cardiomyocytes[1].
ZZ7 (0.1-3 μM, 5 h) fails to degrade BRD9 in DCAF16-knockout (DCAF16-/-) Jurkat/K-562 cells and also loses degradation activity in DCAF16-Cys178 mutant cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 655.79
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Formule C36H45N7O5
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SMILES
CC(N1CCN(C2COC2)CC1)(C)/C=C(C(N3CCN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)CC3)=O)\C#N
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Synonyms
ZZ7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZZ7-23-022 Related Classifications
HY-178345 Related Classifications
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