9002-71-5
Chemical Structure
Thyrotropin
Synonym(s): TSH; Pretiron
- CAS. Nr.: 9002-71-5
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Thyrotropin]
Biological Activity: Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism[1][2][3][4][13].
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Thyrotropin | Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism. | |||||||||||||||||||||
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Bovine Thyrotropin | Bovine Thyrotropin is a pituitary glycoprotein hormone derived from cattle, with identical properties to thyroid-stimulating hormone (TSH). Bovine Thyrotropin stimulates thyroid function and is used to differentiate between primary and secondary hypothyroidism. Bovine Thyrotropin can induce increased radioactive iodine uptake in metastatic thyroid cancer lesions, and long-term administration leads to the production of neutralizing antibodies and hemagglutinating antibodies. Bovine Thyrotropin is applicable to research related to metastatic thyroid cancer. | |||||||||||||||||||||
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[U-15N]-TSH | [U-15N]-TSH is the 15N-labeled TSH. Thyroid-stimulating hormone (TSH) dysfunction is closely associated with primary and secondary thyroid disorders and serves as a key biomarker for the diagnosis and classification of thyroid diseases. This isotope can be used in NMR studies of disease mechanisms and in mass spectrometry analysis. | |||||||||||||||||||||
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References
- [1]. Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60(11):374-7. [Content Brief]
- [2]. Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13(3):596-611. [Content Brief]
- [3]. Kim SM, et al. Thyrotropin, Hyperthyroidism, and Bone Mass[J]. J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4809-e4821. [Content Brief]
- [4]. Chandrasekar A, et al. Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes[J]. Thyroid. 2024 Feb;34(2):261-273. [Content Brief]
- [13]. Li X, et al. Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Endocrinology. 1999 Dec;140(12):5962-70. [Content Brief]
