9002-71-5
Chemical Structure
Thyrotropin
Synonym(s): TSH; Pretiron
- CAS No.: 9002-71-5
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Thyrotropin]
Biological Activity: Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism[1][2][3][4][13].
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Thyrotropin | Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism. | |||||||||||||||||||||
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Bovine Thyrotropin | Bovine Thyrotropin is a glycoprotein hormone. Bovine Thyrotropin can stimulate thyroid follicular cells of other species. | |||||||||||||||||||||
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- [1]. Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60(11):374-7. [Content Brief]
- [2]. Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13(3):596-611. [Content Brief]
- [3]. Kim SM, et al. Thyrotropin, Hyperthyroidism, and Bone Mass[J]. J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4809-e4821. [Content Brief]
- [4]. Chandrasekar A, et al. Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes[J]. Thyroid. 2024 Feb;34(2):261-273. [Content Brief]
- [13]. Li X, et al. Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Endocrinology. 1999 Dec;140(12):5962-70. [Content Brief]
Keywords
