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  4. Cefetamet pivoxyl

Cefetamet pivoxyl  (Synonyms: Ro 15-8075 free base)

Cat. No.: HY-B1894 Purity: 95.0%
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Cefetamet pivoxyl (Ro 15-8075 free base) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, *Neisseria*, *Haemophilus*) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae).

For research use only. We do not sell to patients.

Cefetamet pivoxyl

Cefetamet pivoxyl Chemical Structure

CAS No. : 65243-33-6

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Cefetamet pivoxyl Related Antibodies

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Description

Cefetamet pivoxyl (Ro 15-8075 free base) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, *Neisseria*, *Haemophilus*) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae)[1][2].

In Vitro

Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (e.g., Enterobacteriaceae, *Neisseria*, *Haemophilus*) and some Gram-positive bacteria (e.g., non-enterococcal streptococci)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefetamet pivoxyl Related Antibodies
In Vivo

Cefetamet pivoxyl (administered orally at 1 and 3 hours post-infection) exhibits potent in vivo antibacterial activity against Gram-positive (S. pyogenes) and Gram-negative (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae) strains, but shows no significant activity against S. aureus[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain[2]
Dosage: ED50 0.11 mg/kg (S. pyogenes); ED50 0.73 mg/kg (E. coli); ED50 2.2 mg/kg (K. pneumoniae); ED50 1.8 mg/kg (S. marcescens); ED50 1.2 mg/kg (P. vulgaris); ED50 0.45 mg/kg (P. mirabilis); ED50 <2 mg/kg (H. influenzae); ED50 >25 mg/kg (S. aureus)
Administration: p.o.; at 1 and 3 hours post-challenge
Result: Achieved an ED50 of 0.11 mg/kg against S. pyogenes.
Achieved an ED50 of 0.73 mg/kg against E. coli.
Achieved an ED50 of 2.2 mg/kg against K. pneumoniae.
Achieved an ED50 of 1.8 mg/kg against S. marcescens.
Achieved an ED50 of 1.2 mg/kg against P. vulgaris.
Achieved an ED50 of 0.45 mg/kg against P. mirabilis.
Achieved an ED50 of <2 mg/kg against H. influenzae.
Showed no significant activity against S. aureus, with an ED50 >25 mg/kg.
Molecular Weight

511.57

Formula

C20H25N5O7S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation
References
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Cefetamet pivoxyl Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefetamet pivoxyl65243-33-6Ro 15-8075AntibioticBacterialVibrionaceaeLegionella pneumophilapenicillin-binding proteins 3aerobic gram-negative bacteriaEscherichia coli ATCC 25922penicillin-binding proteins IaCampylobacter jejunienteropathogenic Enterobacteriaceaegram-positive bacteriapenicillin-binding proteins IbInhibitorinhibitorinhibit

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