Cefetamet pivoxyl
Based on 1 Customer Validation
Cefetamet pivoxyl (Ro 15-8075 free base) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, Neisseria, Haemophilus) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae).
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- Reinheit : 95.0%
- CAS. Nr.: 65243-33-6
- Formel: C20H25N5O7S2
- Molecular Weight:511.57
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (e.g., Enterobacteriaceae, *Neisseria*, *Haemophilus*) and some Gram-positive bacteria (e.g., non-enterococcal streptococci)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain[2]
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Dosage:ED50 0.11 mg/kg (S. pyogenes); ED50 0.73 mg/kg (E. coli); ED50 2.2 mg/kg (K. pneumoniae); ED50 1.8 mg/kg (S. marcescens); ED50 1.2 mg/kg (P. vulgaris); ED50 0.45 mg/kg (P. mirabilis); ED50 <2 mg/kg (H. influenzae); ED50 >25 mg/kg (S. aureus)
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Administration:p.o.; at 1 and 3 hours post-challenge
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Result:Achieved an ED50 of 0.11 mg/kg against S. pyogenes.
Achieved an ED50 of 0.73 mg/kg against E. coli.
Achieved an ED50 of 2.2 mg/kg against K. pneumoniae.
Achieved an ED50 of 1.8 mg/kg against S. marcescens.
Achieved an ED50 of 1.2 mg/kg against P. vulgaris.
Achieved an ED50 of 0.45 mg/kg against P. mirabilis.
Achieved an ED50 of <2 mg/kg against H. influenzae.
Showed no significant activity against S. aureus, with an ED50 >25 mg/kg.
Chemical Information
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CAS. Nr. 65243-33-6
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Appearance Solid
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Molecular Weight 511.57
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Formel C20H25N5O7S2
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Color Off-white to light yellow
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SMILES
O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O
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Synonyms
Ro 15-8075 free base
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Hohl P, et al. Cefetamet pivoxil: bacteriostatic and bactericidal activity of the free acid against 355 gram-negative rods. Infection. 1988;16(3):194-198. [Content Brief]
[2]. Bryson HM, et al. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1993 Apr;45(4):589-621. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cefetamet pivoxyl Related Classifications
HY-B1894 Related Classifications
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Keywords
- Cefetamet pivoxyl
- 65243-33-6
- Ro 15-8075
- Antibiotic
- Bacterial
- Vibrionaceae
- Legionella pneumophila
- penicillin-binding proteins 3
- aerobic gram-negative bacteria
- Escherichia coli ATCC 25922
- penicillin-binding proteins Ia
- Campylobacter jejuni
- enteropathogenic Enterobacteriaceae
- gram-positive bacteria
- penicillin-binding proteins Ib
- Inhibitor
- inhibitor
- inhibit