country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-N18471A

Copy Link Print Information

5,7-Dihydroxytryptamine hydrobromide

(Synonyms: 5,7-DHP hydrobromide)

5,7-Dihydroxytryptamine (5,7-DHT) hydrobromide is an autofluorescent (Ex ≈ 365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine hydrobromide can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine hydrobromide can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1841081-30-8
Formel: C₁₀H₁₃BrN₂O₂
Molecular Weight:273.13

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

5,7-Dihydroxytryptamine hydrobromide Chemical Structure

CAS. Nr.: 1841081-30-8

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen :

MAO-A
MAO-B

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

5,7-dihydroxytryptamine hydrobromide (25 μM; 60 min at 37°C) specifically labels serotonergic cells (but not dopaminergic cells) in 10-day-old primary mesencephalic cultures from 14-day-old Wistar rat foetuses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

5,7-Dihydroxytryptamine (12.5-50.0 μg; intracerebroventricular administration; single dose) hydrobromide depletes norepinephrine and 5-HT in the hippocampus of mice. The depletion of norepinephrine is blocked by non-selective MAO inhibition but not by selective MAO-B inhibition^[1].
5,7-Dihydroxytryptamine (10 μg base; intracerebroventricular injection; single administration; 10 days prior to seizure induction) hydrobromide depletes 5-HT levels in the spinal cord of rats, but does not affect electrically induced spinal cord seizures in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (adult male, 175-200 g at surgery)^[1]
Dosage:

8 μg
Administration:

bilateral stereotaxic infusion into nucleus accumbens; over 2 min, injector left in place for 1 additional min post-infusion
Result:

Increased mean amplitude of the acoustic startle reflex significantly across all stimulus intensities in the absence of background noise compared to the Sham-lesion group.
Showed no significant differences in startle amplitude between the DHT-lesion, Sham-lesion, and intact groups at any stimulus intensity in the presence of background noise.
Confirmed nearly complete loss of serotonergic neurons in the nucleus accumbens via immunohistochemistry.

Animal Model:

C57BL/6 (male, 2 and 10 months old, 20-30 g)^[2]
Dosage:

12.5 μg; 25 μg; 50 μg
Administration:

i.c.v.; single dose
Result:

Had a damaging effect on the noradrenergic system, and this effect was independent of the age of the mice.
Exerted stronger toxic effects on serotonergic neurons in young individuals.

Animal Model:

M/511-Wistar (male, 240-280 g)^[4]
Dosage:

4 µg (calculated as the base) per injection site
Administration:

stereotactic injection; 1 µl/min rate; needle left in situ for 1 min post-injection
Result:

Reduced ³H-5-HT uptake but did not change ³H-NA uptake in the cortex (medial bundle lesion group).
Reduced ³H-NA uptake to 75% of control (non-significant) in the cortex (medial plus lateral bundle lesion group).
Induced mouse killing behavior in 4 of 8 rats (medial bundle lesion group) and 6 of 7 rats (medial plus lateral bundle lesion group).
Required significantly more trials to reach habituation criterion for touch (both lesion groups).
Required significantly more trials for acoustic stimulation habituation (only medial plus lateral lesion group).
Showed a significantly higher number of boxing positions in the shock elicited fighting test (both lesion groups).
Showed no significant changes in home cage activity (both lesion groups).

Chemical Information

CAS. Nr. 1841081-30-8
Molecular Weight 273.13
Formel C₁₀H₁₃BrN₂O₂
SMILES

NCCC1=CNC2=C(C=C(C=C12)O)O.Br
Synonyms

5,7-DHP hydrobromide
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Finnegan KT, et al. The amine-depleting effects of 5,7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. Brain Res. 1989;496(1-2):251-256. [Content Brief]

[2]. Franke H, et al. 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(4):315-318. [Content Brief]

[3]. Jobe P C, et al. The relative significance of spinal cord norepinephrine and 5-hydroxytryptamine in electrically-induced seizure in the rat[J]. Neuropharmacology, 1978, 17(3): 185-190.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

5,7-Dihydroxytryptamine hydrobromide

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

5,7-Dihydroxytryptamine hydrobromide

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

5,7-Dihydroxytryptamine hydrobromide Related Classifications

HY-N18471A Related Classifications