5,7-Dihydroxytryptamine
5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons.
For research use only. We do not sell to patients.
- CAS No.: 31363-74-3
- Formula: C10H12N2O2
- Molecular Weight:192.21
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All 5-HT Receptor Isoforms
More
Biological Activity
|
MAO-A |
5,7-dihydroxytryptamine (25 μM; 60 min at 37°C) specifically labels serotonergic cells (but not dopaminergic cells) in 10-day-old primary mesencephalic cultures from 14-day-old Wistar rat foetuses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
5,7-Dihydroxytryptamine (10 μg base; intracerebroventricular injection; single administration; 10 days prior to seizure induction) depletes 5-HT levels in the spinal cord of rats, but does not affect electrically induced spinal cord seizures in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 male mice (2 months old, 20-30 g)[1]
-
Dosage:12.5, 25, 50.0 μg
-
Administration:intracerebroventricularly; single dose
-
Result:Depleted hippocampal norepinephrine by 68% and serotonin by 71% in mice not pretreated with MAO inhibitors.
-
Animal Model:Sprague-Dawley (female, 180-220 g)[3]
-
Dosage:10 µg of the base
-
Administration:i.c.v.; single dose; 10 days before seizure induction
-
Result:Reduced spinal cord 5-hydroxytryptamine levels to 0.21 µg/g ± 0.04; produced no changes in spinal cord norepinephrine content or electrically-induced spinal cord seizure parameters (duration of tonic flexion, tonic extension, or total seizure duration)
Chemical Information
-
CAS No. 31363-74-3
-
Molecular Weight 192.21
-
Formula C10H12N2O2
-
SMILES
NCCC1=CNC2=C(O)C=C(O)C=C12
-
Synonyms
5,7-DHP
-
Structure Classification
-
Initial Source
rat
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Finnegan KT, et al. The amine-depleting effects of 5,7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. Brain Res. 1989;496(1-2):251-256. [Content Brief]
[2]. Franke H, et al. 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(4):315-318. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5,7-Dihydroxytryptamine Related Classifications
Cat. No.: HY-N18471
Powered by Bioz
- 5,7-Dihydroxytryptamine
- 31363-74-3
- 5,7-DHP
- Monoamine Oxidase
- 5-HT Receptor
- spinal cord 5-hydroxytryptamine
- Monoamine oxidase A (MAO A)
- C57BL/6 mice
- serotonin transporter
- hippocampal serotonin
- serotonergic neurone
- hippocampal norepinephrine
- noradrenergic neurone
- Wistar rat foetuses
- central nervous system 5-hydroxytryptaminergic neurone
- Inhibitor
- inhibitor
- inhibit