2. Neuronal Signaling GPCR/G Protein
  3. Monoamine Oxidase 5-HT Receptor
  4. 5,7-Dihydroxytryptamine

5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons.

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5,7-Dihydroxytryptamine

5,7-Dihydroxytryptamine Chemical Structure

CAS No. : 31363-74-3

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5,7-Dihydroxytryptamine Related Antibodies

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Description

5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons[1][2][3].

IC50 & Target

MAO-A

 

In Vitro

5,7-dihydroxytryptamine (25 μM; 60 min at 37°C) specifically labels serotonergic cells (but not dopaminergic cells) in 10-day-old primary mesencephalic cultures from 14-day-old Wistar rat foetuses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5,7-Dihydroxytryptamine Related Antibodies
In Vivo

5,7-Dihydroxytryptamine (12.5-50.0 μg; intracerebroventricular administration; single dose) depletes norepinephrine and 5-HT in the hippocampus of mice. The depletion of norepinephrine is blocked by non-selective MAO inhibition but not by selective MAO-B inhibition[1].
5,7-Dihydroxytryptamine (10 μg base; intracerebroventricular injection; single administration; 10 days prior to seizure induction) depletes 5-HT levels in the spinal cord of rats, but does not affect electrically induced spinal cord seizures in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 male mice (2 months old, 20-30 g)[1]
Dosage: 12.5, 25, 50.0 μg
Administration: intracerebroventricularly; single dose
Result: Depleted hippocampal norepinephrine by 68% and serotonin by 71% in mice not pretreated with MAO inhibitors.
Animal Model: Sprague-Dawley (female, 180-220 g)[3]
Dosage: 10 µg of the base
Administration: i.c.v.; single dose; 10 days before seizure induction
Result: Reduced spinal cord 5-hydroxytryptamine levels to 0.21 µg/g ± 0.04; produced no changes in spinal cord norepinephrine content or electrically-induced spinal cord seizure parameters (duration of tonic flexion, tonic extension, or total seizure duration)
Molecular Weight

192.21

Formula

C10H12N2O2
CAS No.
SMILES

NCCC1=CNC2=C(O)C=C(O)C=C12
Structure Classification
Initial Source

rat
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5,7-Dihydroxytryptamine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5,7-Dihydroxytryptamine31363-74-35,7-DHPMonoamine Oxidase5-HT ReceptorMAOSerotonin Receptor5-hydroxytryptamine Receptorspinal cord 5-hydroxytryptamineMonoamine oxidase A (MAO A)C57BL/6 miceserotonin transporterhippocampal serotoninserotonergic neuronehippocampal norepinephrinenoradrenergic neuroneWistar rat foetusescentral nervous system 5-hydroxytryptaminergic neuroneInhibitorinhibitorinhibit

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