31363-74-3
Chemical Structure
5,7-Dihydroxytryptamine
Synonym(s): 5,7-DHP
- CAS No.: 31363-74-3
- Formula:C10H12N2O2
- Molecular Weight:192.21
InChIKey: LXWHQTNFZDTKBH-UHFFFAOYSA-N
SMILES: NCCC1=CNC2=C(O)C=C(O)C=C12
Biological Activity: 5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons[1][2][3].
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5,7-Dihydroxytryptamine | 5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons. | |||||||||||||||||||||
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References
- [1]. Finnegan KT, et al. The amine-depleting effects of 5,7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. Brain Res. 1989;496(1-2):251-256. [Content Brief]
- [2]. Franke H, et al. 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(4):315-318. [Content Brief]
- [3]. Jobe P C, et al. The relative significance of spinal cord norepinephrine and 5-hydroxytryptamine in electrically-induced seizure in the rat[J]. Neuropharmacology, 1978, 17(3): 185-190.
