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Art. -Nr.: HY-146098

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Antibacterial agent 105

Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones show antibacterial activity against M. tuberculosis with antibacterial activity (MIC₉₀=2.64 μM). Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC₉₀s of 11.18, 11.18, 0.70, 1.40, 44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum, BCG, E. aerogenes and S. aureus, respectively.

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CAS. Nr.: 2364493-24-1
Formel: C₁₄H₉N₃O₅
Molecular Weight:299.24

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Antibacterial agent 105 Chemical Structure

CAS. Nr.: 2364493-24-1

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Biologische Aktivität
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Chemical Information
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Biologische Aktivität

Beschreibung

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In Vitro

Antibacterial agent 105 (compound 17) has inhibitory effect on the growth of M. tuberculosis replicating in vitro cultured macrophages^[1].
Antibacterial agent 105 (compound 17) (24 hours) has no toxicity on Vero cells line and human macrophages^[1].
Antibacterial agent 105 (compound 17) has antibacterial activities against FQ resistant bacteria and XDR-TB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2364493-24-1
Molecular Weight 299.24
Formel C₁₄H₉N₃O₅
SMILES

O=C(C1=CN(C)C2=C(C1=O)C=C([N+]([O-])=O)C3=CC=CN=C32)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Songuigama Coulibaly, et al. Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis. Eur J Med Chem. 2020 Dec 1;207:112821. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Antibacterial agent 105

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