Citicoline-d9 sodium
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Citicoline-d9 (Cytidine diphosphate-choline-d9) sodium is the deuterium labeled Citicoline sodium (HY-B0739A). Citicoline sodium is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline sodium inhibits reactive oxygen species (ROS) and apoptosis. Citicoline sodium can be used for neurological disease and hearing loss study.
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- Formel: C14H16D9N4NaO11P2
- Molecular Weight:519.36
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Caspase-8 |
Caspase-9 |
Caspase 3 |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 33818-15-4
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Appearance Solid
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Molecular Weight 519.36
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Formel C14H16D9N4NaO11P2
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Color Off-white to light yellow
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SMILES
NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OCC[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([O-])=O)(O[Na])=O)O2)=NC1=O
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Synonyms
Cytidine diphosphate-choline-d9 sodium; CDP-Choline-d9 sodium; Cytidine 5'-diphosphocholine-d9 sodium
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (192.54 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703. [Content Brief]
[3]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7. [Content Brief]
[4]. Zhong Z, et al. Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage. Front Cell Dev Biol. 2020 Aug 31;8:712. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.9254 mL | 9.6272 mL | 19.2545 mL | 48.1362 mL |
| 5 mM | 0.3851 mL | 1.9254 mL | 3.8509 mL | 9.6272 mL | |
| 10 mM | 0.1925 mL | 0.9627 mL | 1.9254 mL | 4.8136 mL | |
| 15 mM | 0.1284 mL | 0.6418 mL | 1.2836 mL | 3.2091 mL | |
| 20 mM | 0.0963 mL | 0.4814 mL | 0.9627 mL | 2.4068 mL | |
| 25 mM | 0.0770 mL | 0.3851 mL | 0.7702 mL | 1.9254 mL | |
| 30 mM | 0.0642 mL | 0.3209 mL | 0.6418 mL | 1.6045 mL | |
| 40 mM | 0.0481 mL | 0.2407 mL | 0.4814 mL | 1.2034 mL | |
| 50 mM | 0.0385 mL | 0.1925 mL | 0.3851 mL | 0.9627 mL | |
| 60 mM | 0.0321 mL | 0.1605 mL | 0.3209 mL | 0.8023 mL | |
| 80 mM | 0.0241 mL | 0.1203 mL | 0.2407 mL | 0.6017 mL | |
| 100 mM | 0.0193 mL | 0.0963 mL | 0.1925 mL | 0.4814 mL |
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