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Cofetuzumab

(Synonyms: PF-06523435; hu24)
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Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 99.31%
  • CAS. Nr.: 1869928-62-0
  • Molecular Weight:146.7 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Cofetuzumab
  • Experimental Validation Results for Cofetuzumab
  • Experimental Validation Results for Cofetuzumab
  • Cofetuzumab Chemical Structure
    Cofetuzumab Chemical Structure
CAS. Nr.: 1869928-62-0
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human PTK7/CCK4, Fc Tag can bind Cofetuzumab. The EC50 for this effect is 21.74 ng/mL.

  • 1/16

    Flow Cytometry analysis of Hela cells labelling PTK7/CCK4 (red) with Cofetuzumab (anti-PTK7/CCK4) (HY-P99828). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

  • Cofetuzumab Chemical Structure
    1/16
  • Cofetuzumab
  • Immobilized Human PTK7/CCK4, Fc Tag can bind Cofetuzumab. The EC50 for this effect is 21.74 ng/mL.
  • Flow Cytometry analysis of Hela cells labelling PTK7/CCK4 (red) with Cofetuzumab (anti-PTK7/CCK4) (HY-P99828). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.