PTK7 - protein tyrosine kinase 7 (inactive) Gene

Also Known as CCK4; CCK-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5754

About PTK7

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,076,314-43,161,715 (from NCBI)

This gene has 20 transcripts (splice variants) and 229 orthologues. Broad expression in endometrium (RPKM 43.5), ovary (RPKM 31.2) and 19 other tissues.

Summary

This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PTK7 Products (5)

mRNA Protein Name
NM_001270398.2 NP_001257327.1 inactive tyrosine-protein kinase 7 isoform e
NM_002821.5 NP_002812.2 inactive tyrosine-protein kinase 7 isoform a precursor
NM_152880.4 NP_690619.1 inactive tyrosine-protein kinase 7 isoform b precursor
NM_152881.4 NP_690620.1 inactive tyrosine-protein kinase 7 isoform c precursor
NM_152882.4 NP_690621.1 inactive tyrosine-protein kinase 7 isoform d precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21132015 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20837484 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
20837484 GOA
involved in cellular response to retinoic acid IMP
IMP: Inferred from mutant phenotype
17910947 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
21132015 GOA
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17910947 GOA
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
20837484 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTK7 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (33 - 114)

Ig_2

Ig_2: Immunoglobulin domain (137 - 217)

I-set

I-set: Immunoglobulin I-set domain (229 - 302)

I-set

I-set: Immunoglobulin I-set domain (347 - 408)

I-set

I-set: Immunoglobulin I-set domain (415 - 498)

I-set

I-set: Immunoglobulin I-set domain (503 - 588)

I-set

I-set: Immunoglobulin I-set domain (593 - 679)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (799 - 1061)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1070 a.a.
Protein Preferred Names Protein Names

inactive tyrosine-protein kinase 7

  • PTK7 protein tyrosine kinase 7

PTK7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTK7 Q13308 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
PTK7 Q13308 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
PTK7 Q13308 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
PTK7 Q13308 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
PTK7 Q13308 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
PTK7 Q13308 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
PTK7 Q13308 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
PTK7 Q13308 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
PTK7 Q13308 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
PTK7 Q13308 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
21132015
Intra
PTK7 Q13308 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
PTK7 Q13308 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
PTK7 Q13308 MDFI Homo sapiens Q99750
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTK7 Proteins

Cat. No. Product Name Accession Purity
HY-P71821 PTK7 Protein, Human (P.pastoris, His) Q13308-1 (A31-T704) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78398 PTK7 Protein, Human (HEK293, His) Q13308-1 (A31-T704) ≥ 95%, as determined by Bis-Tris PAGE.

PTK7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84534 CCK-4 Antibody (YA4231) WB, IHC-P, ELISA Human
HY-P84534A CCK-4 Antibody (YA4231)(PBS only) WB, IHC-P, ELISA Human
HY-P85079 CCK-4 Antibody (YA4771) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Agoraphobia

  • Fear Of Open Spaces

  • Phobia Of Going Out
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Scoliosis
Myelomeningocele

  • Meningomyelocele
Phobic Disorder

  • Phobic Disorders

  • Phobic Anxiety Disorder
Syringomyelia

  • Hydromyelia
Strabismus

  • Strabismus, Susceptibility To

  • Strabismus, Susceptibility To, 1

  • Strabismus 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99828 Cofetuzumab 99.31% Phase 1
HY-P99829 Cofetuzumab pelidotin Inhibitor 99.18% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160493 PTK7/β-catenin-IN-6 Inhibitor / Unkown
HY-160488 PTK7/β-catenin-IN-1 Inhibitor 99.99% Unkown
HY-160489 PTK7/β-catenin-IN-2 Inhibitor 96.96% Unkown
HY-182914 NGI-189 99.29% Unkown
HY-RS11404 PTK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17543 Ptk7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24001 Ptk7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTK7 VGNC VGNC:54670
Felis catus PTK7 VGNC VGNC:102498
Macaca mulatta PTK7 VGNC VGNC:83451
Mus musculus PTK7 MGD MGI:1918711
Rattus norvegicus PTK7 RGD RGD:1310472
Others PTK7 NCBI