CCK-4 Antibody (YA4771)
(Synonyms: PTK7; CCK4; Inactive tyrosine-protein kinase 7; Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7)CCK-4 Antibody (YA4771) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CCK-4.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 | 1:50-200 |
Product Details
CCK-4 Antibody (YA4771) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CCK-4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 118 kDa;
Purified recombinant fragment of human CCK-4 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CCK-4 is an Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis
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Subcellular Localization
Membrane; Single-pass type I membrane protein; Cell junction
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Expression
Tissue_specificity:It is highly expressed in the lungs, liver, pancreas, kidneys, placenta, and melanocytes. It is weakly expressed in the thyroid, ovaries, brain, heart, and skeletal muscle. It is also expressed in erythroleukemia cells, but not in the colon.
Induction:Higher expression in cell lines established from normal non-tumorigenic tissues compared to cell lines established from highly metastatic invasive carcinomas (at protein level) -
Isoforms & Post-Translational Modification
Q13308 has 6 isomers: Q13308-1: 118392 Da (predicted); Q13308-2: 113805 Da (predicted); Q13308-3: 103581 Da (predicted); Q13308-4: 112261 Da (predicted); Q13308-5: 89764 Da (predicted); Q13308-6: 119197 Da (predicted).
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway -
Subunit
Interacts with CTNNB1
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SwissProt ID
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Synonyms
PTK7; CCK4; Inactive tyrosine-protein kinase 7; Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7
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