Art. -Nr.: HY-N6771

Cyclopiazonic acid

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B^[1][4][5].

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Reinheit: 99.86%
CAS. Nr.: 18172-33-3
Formel: C₂₀H₂₀N₂O₃
Molecular Weight:336.38

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cyclopiazonic acid Chemical Structure

CAS. Nr.: 18172-33-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	0.01 μM Compound: 1, CPA	Inhibition of Heliothis virescens SERCA expressed in Sf9 cells assessed as ATP depletion measured after 60 mins by luciferin/luciferase coupled reporter gene assay Inhibition of Heliothis virescens SERCA expressed in Sf9 cells assessed as ATP depletion measured after 60 mins by luciferin/luciferase coupled reporter gene assay	[PMID: 21719297]

In Vitro

Cyclopiazonic acid (10 μM) enhances 5-HT-induced contraction and reduces the antagonistic effect of 5-HT receptors in rat thoracic aorta ^[2].
Cyclopiazonic acid (10 μM, 48h) has an inhibitory effect on pacemaker current in sinoatrial node cells^[3].
Cyclopiazonic acid (10 μM, 48h) exhibits antiviral activity against human respiratory syncytial virus by increasing intracellular calcium concentration in HEp-2 cells^[4].
Cyclopiazonic acid (10 μM) inhibits the formation of certain metabolites of caffeine and testosterone and suppresses the biological activation of aflatoxin B through cytochrome P450 enzymes^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3].

Cell Line:

Isolated sinoatrial node (SAN) cells
Concentration:

10 μM
Incubation Time:

48 h
Result:

Reduced the expression of HCN4 protein.

In Vivo

Cyclopiazonic acid (0.03, 0.06, 0.12 mg/kg; once a day; 28 days; i.p.) induces p53 dependent cell apoptosis and reproductive toxicity in mouse testes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male mice^[1].
Dosage:

0.03, 0.06, 0.12 mg/kg
Administration:

Intraperitoneal injection (i.p.); once a day; 28 days
Result:

Increased the levels of malondialdehyde (MDA), NO, and CO in testicular tissue, and reduced the concentration of total thiol molecules (TTM) and the level of total antioxidant capacity (TAC).

Chemical Information

CAS. Nr. 18172-33-3
Appearance Solid
Molecular Weight 336.38
Formel C₂₀H₂₀N₂O₃
Color Off-white to yellow
SMILES

O=C1C(C(C)=O)=C(O)[C@@]([C@]23[H])([H])N1C(C)(C)[C@]2([H])CC4=CC=CC5=C4C3=CN5
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganisms
Aspergillus flavus
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (7)

All OthersWBCell Proliferation/Viability Assay

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Journal Impact Factor

Nat Commun

NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization. [Abstract]

2025 Aug 29;16(1):8074. PMID: 40883305
J Clin Invest

Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice. [Abstract]

2022 Apr 15;132(8):e149160. PMID: 35426376

Cyclopiazonic acid purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2022 Apr 15;132(8):e149160. [Abstract]

CPA (Cyclopiazonic acid: 5 μM) inhibited SERCA and promoted Ca2+ efflux from ER.
Genes Dis

STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma. [Abstract]

2024 Mar 28;11(6):101281. PMID: 39281833

Cyclopiazonic acid purchased from MedChemExpress. Usage Cited in: Genes Dis. 2024 Mar 28;11(6):101281. [Abstract]

Calcium imaging was applied to analyze the calcium mobilization in Con- and SR-Hep3B and MHCC97H cells, respectively upon cyclopiazonic acid (CPA) (200 μM) stimulation.
Alzheimers Res Ther

Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice. [Abstract]

2025 Dec 1;17(1):253. PMID: 41327376

Cyclopiazonic acid purchased from MedChemExpress. Usage Cited in: Alzheimers Res Ther. 2025 Dec 1;17(1):253. [Abstract]

Neuronal MMP decrease induced by Glu exposure was abolished by Ca2+-free buffer, suppressed by preincubation with BAPTA-AM (10 μM; 30 min) but not CPA (Cyclopiazonic acid: 10 μM; 10 min).
Cell Rep

Goblet cell-expressed microprotein FXYD3 determines gut homeostasis by maintaining mucus barrier integrity. [Abstract]

2025 Nov 25;44(11):116502. PMID: 41187059
Cell Rep

Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington's disease. [Abstract]

2023 Dec 26;42(12):113573. PMID: 38096054
Mol Biol Rep

Mechanism of Ca2+ overload caused by STIM1/ORAI1 activation of store-operated Ca2+ entry (SOCE) in hydrogen peroxide-induced mitochondrial damage and apoptosis in human primary melanocytes. [Abstract]

2025 Feb 12;52(1):223. PMID: 39937331

Cyclopiazonic acid purchased from MedChemExpress. Usage Cited in: Mol Biol Rep. 2025 Feb 12;52(1):223. [Abstract]

Protein expression of STIM1 and ORAI1 in melanocytes pretreated with CPA (Cyclopiazonic acid: 2.5 µM).

Cyclopiazonic acid purchased from MedChemExpress. Usage Cited in: Mol Biol Rep. 2025 Feb 12;52(1):223. [Abstract]

Cell viability of STIM1 and ORAI1 in melanocytes pretreated with CPA (Cyclopiazonic acid: 2.5 µM).

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (297.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9728 mL

14.8641 mL

29.7283 mL

5 mM

0.5946 mL

2.9728 mL

5.9457 mL

10 mM

0.2973 mL

1.4864 mL

2.9728 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
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- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bonyadi F, et al. Cyclopiazonic acid induced p53-dependent apoptosis in the testis of mice: Another male related risk factor of infertility. Environ Toxicol. 2021 May;36(5):903-913. [Content Brief]

[2]. Selli C, et al. Cyclopiazonic acid alters serotonin-induced responses in rat thoracic aorta. Vascul Pharmacol. 2014 May-Jun;61(2-3):43-8. [Content Brief]

[3]. Chen Q, et al. Inhibitory Effects of Cyclopiazonic Acid on the Pacemaker Current in Sinoatrial Nodal Cells. Neuroscience. 2020 May 1;433:230-240. [Content Brief]

[4]. Cui R, et al. Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus. Antiviral Res. 2016 Aug;132:38-45. [Content Brief]

[5]. Kuilman-Wahls ME, et al. Cyclopiazonic acid inhibits mutagenic action of aflatoxin B(1). Environ Toxicol Pharmacol. 2002 Jul;11(3-4):207-12. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9728 mL	14.8641 mL	29.7283 mL	74.3207 mL
	5 mM	0.5946 mL	2.9728 mL	5.9457 mL	14.8641 mL
	10 mM	0.2973 mL	1.4864 mL	2.9728 mL	7.4321 mL
	15 mM	0.1982 mL	0.9909 mL	1.9819 mL	4.9547 mL
	20 mM	0.1486 mL	0.7432 mL	1.4864 mL	3.7160 mL
	25 mM	0.1189 mL	0.5946 mL	1.1891 mL	2.9728 mL
	30 mM	0.0991 mL	0.4955 mL	0.9909 mL	2.4774 mL
	40 mM	0.0743 mL	0.3716 mL	0.7432 mL	1.8580 mL
	50 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4864 mL
	60 mM	0.0495 mL	0.2477 mL	0.4955 mL	1.2387 mL
	80 mM	0.0372 mL	0.1858 mL	0.3716 mL	0.9290 mL
	100 mM	0.0297 mL	0.1486 mL	0.2973 mL	0.7432 mL

Keywords

Cyclopiazonic acid

7 Cited Publications

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Cyclopiazonic acid

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Publications Citing Use of MedChemExpress (MCE) Cyclopiazonic acid

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cyclopiazonic acid Related Classifications

HY-N6771 Related Classifications