Timp2 - tissue inhibitor of metalloproteinase 2 Gene

Also Known as Timp-2; D11Bwg1104e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21858

Summary

Enables enzyme activator activity; Integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]

Timp2 Products (1)

mRNA Protein Name
NM_011594.3 NP_035724.2 metalloproteinase inhibitor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables enzyme activator activity IMP
IMP: Inferred from mutant phenotype
10827175 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
15901773 MGI
enables metalloendopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
10827176 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15901773 MGI
acts upstream of or within regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15901773 MGI
acts upstream of or within regulation of neuron differentiation IDA
IDA: Inferred from direct assay
15901773 MGI
acts upstream of or within regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15901773 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in basement membrane IDA
IDA: Inferred from direct assay
12950084 MGI
located in cell surface IDA
IDA: Inferred from direct assay
15901773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloproteinase inhibitor 2

  • tissue inhibitor of metalloproteinases 2

Recombinant Timp2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71137 TIMP-2 Protein, Mouse (HEK293, His) P25785 (C27-P220) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P71137A TIMP-2 Protein, Mouse (HEK293, C-His) P25785 (C27-P220) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-N19029 Vernodalin / Unkown
HY-RS14539 TIMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W012856 3-Ethyltoluene / Unkown
HY-RS17383 Timp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23838 Timp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Timp2 NCBI NCBI:7077