ARHGEF40 - Rho guanine nucleotide exchange factor 40 Gene

Also Known as SOLO

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55701

About ARHGEF40

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,061,264-21,090,248 (from NCBI)

This gene has 8 transcripts (splice variants), 107 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 21.4), adrenal (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. [provided by RefSeq, Mar 2014]

ARHGEF40 Products (3)

mRNA Protein Name
NM_001278529.2 NP_001265458.1 rho guanine nucleotide exchange factor 40 isoform 2
NM_001278530.2 NP_001265459.1 rho guanine nucleotide exchange factor 40 isoform 3
NM_018071.5 NP_060541.3 rho guanine nucleotide exchange factor 40 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF40 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (1090 - 1243)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1519 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 40

  • Rho guanine nucleotide exchange factor (GEF) 40

Related Diseases

Diseases Alias
Usher Syndrome, Type Id

  • Usher Syndrome Type 1d

  • USH1D

  • Usher Syndrome, Type 1d

  • Usher Syndrome Type Id

  • Usher Syndrome, Type Id/F, Digenic

  • Usher Syndrome, Type 1d/F Digenic

  • Usher Syndrome 1d

  • Usher'S Syndrome Type 1d

  • Usher Syndrome 1d/F

  • USH1DF

  • Ush1d/F

  • Usher'S Syndrome Type 1h

  • Usher Syndrome 1h

  • Usher Syndrome Type Ih

  • Usher Syndrome, Type 1d/F
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00961 ARHGEF40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22059 Arhgef40 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28577 Arhgef40 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF40 VGNC VGNC:38089
Bos taurus ARHGEF40 VGNC VGNC:26118
Felis catus ARHGEF40 VGNC VGNC:59908
Mus musculus ARHGEF40 MGD MGI:2685515
Rattus norvegicus ARHGEF40 RGD RGD:1308093
Macaca mulatta ARHGEF40 VGNC VGNC:69907