TIAL1 - TIA1 cytotoxic granule associated RNA binding protein like 1 Gene

Also Known as TCBP; TIAR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7073

About TIAL1

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,573,465-119,596,964 (from NCBI)

This gene has 13 transcripts (splice variants), 116 orthologues and 36 paralogues. Ubiquitous expression in endometrium (RPKM 14.6), lymph node (RPKM 14.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and Apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

TIAL1 Products (8)

mRNA Protein Name
NM_001033925.2 NP_001029097.1 nucleolysin TIAR isoform 2
NM_001323964.2 NP_001310893.1 nucleolysin TIAR isoform 3
NM_001323965.2 NP_001310894.1 nucleolysin TIAR isoform 3
NM_001323967.2 NP_001310896.1 nucleolysin TIAR isoform 3
NM_001323968.2 NP_001310897.1 nucleolysin TIAR isoform 4
NM_001323969.2 NP_001310898.1 nucleolysin TIAR isoform 5
NM_001323970.2 NP_001310899.1 nucleolysin TIAR isoform 6
NM_003252.4 NP_003243.1 nucleolysin TIAR isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
33203680 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables protein-RNA adaptor activity IDA
IDA: Inferred from direct assay
33203680 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
33203680 GOA
involved in positive regulation of hippo signaling IMP
IMP: Inferred from mutant phenotype
33203680 GOA
involved in positive regulation of miRNA-mediated gene silencing IGI
IGI: Inferred from genetic interaction
33203680 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIAL1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (11 - 79)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (99 - 169)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (207 - 271)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

nucleolysin TIAR

  • T-cluster binding protein

TIAL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TIAL1 Q01085 MOV10 Homo sapiens Q9HCE1
Anti Bait CoIP
34517762
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ulcerative Blepharitis
Salpingitis Isthmica Nodosa
Muscular Atrophy

  • Muscle Wasting

  • Amyotrophia

  • Wasting - Muscle

  • Skeletal Muscle Atrophy
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-116079 Diplopterol / Unkown
HY-117733 Zerumin A Inhibitor / Unkown
HY-RS14514 TIAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14520 TIE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15973 BSF-466895 Inhibitor / Unkown
HY-RS19390 Tie1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22860 Tial1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25882 Tie1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29374 Tial1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991384 DX-2240 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TIAL1 VGNC VGNC:35859
Rattus norvegicus TIAL1 RGD RGD:1595845
Macaca mulatta TIAL1 VGNC VGNC:78354
Mus musculus TIAL1 MGD MGI:107913
Canis familiaris TIAL1 VGNC VGNC:47364
Felis catus TIAL1 VGNC VGNC:66182
Others TIAL1 NCBI