H111-H7
Based on 1 Customer Validation
H111-H7 is a WW domain containing E3 ubiquitin 27 protein ligase 2 (WWP2) inhibitor with a KD of 717 nM. H111-H7 inhibits WWP2 expression, restores the succinate dehydrogenase complex subunit C (SDHC) level, and defers the acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition in unilateral kidney ischemia–reperfusion (UIR) mice. H111-H7 can be used for AKI-to-CKD transition research.
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- Reinheit: 98.14%
- CAS. Nr.: 220965-54-8
- Formel: C13H10ClNO3S2
- Molecular Weight:327.81
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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WWP2 717 nM (Kd) |
Chemical Information
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CAS. Nr. 220965-54-8
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Appearance Solid
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Molecular Weight 327.81
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Formel C13H10ClNO3S2
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Color Light yellow to yellow
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SMILES
CC(C1=CC([N+]([O-])=O)=C(S1)SCC2=CC=C(C=C2)Cl)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (305.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0505 mL | 15.2527 mL | 30.5055 mL | 76.2637 mL |
| 5 mM | 0.6101 mL | 3.0505 mL | 6.1011 mL | 15.2527 mL | |
| 10 mM | 0.3051 mL | 1.5253 mL | 3.0505 mL | 7.6264 mL | |
| 15 mM | 0.2034 mL | 1.0168 mL | 2.0337 mL | 5.0842 mL | |
| 20 mM | 0.1525 mL | 0.7626 mL | 1.5253 mL | 3.8132 mL | |
| 25 mM | 0.1220 mL | 0.6101 mL | 1.2202 mL | 3.0505 mL | |
| 30 mM | 0.1017 mL | 0.5084 mL | 1.0168 mL | 2.5421 mL | |
| 40 mM | 0.0763 mL | 0.3813 mL | 0.7626 mL | 1.9066 mL | |
| 50 mM | 0.0610 mL | 0.3051 mL | 0.6101 mL | 1.5253 mL | |
| 60 mM | 0.0508 mL | 0.2542 mL | 0.5084 mL | 1.2711 mL | |
| 80 mM | 0.0381 mL | 0.1907 mL | 0.3813 mL | 0.9533 mL | |
| 100 mM | 0.0305 mL | 0.1525 mL | 0.3051 mL | 0.7626 mL |
H111-H7 Related Classifications
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